5OW1
X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors
Summary for 5OW1
Entry DOI | 10.2210/pdb5ow1/pdb |
Related | 5OVR 5OVX |
Descriptor | Tyrosine-protein phosphatase non-receptor type 5, [[3-(3-cyclohexyl-2-oxidanyl-phenyl)phenyl]-bis(fluoranyl)methyl]phosphonic acid (3 entities in total) |
Functional Keywords | phosphatase, alzheimer's disease, inhibitor, ptpn5, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Endoplasmic reticulum membrane ; Multi-pass membrane protein : P54829 |
Total number of polymer chains | 1 |
Total formula weight | 35619.25 |
Authors | Kack, H.,Wissler, L. (deposition date: 2017-08-30, release date: 2017-11-22, Last modification date: 2024-01-17) |
Primary citation | Witten, M.R.,Wissler, L.,Snow, M.,Geschwindner, S.,Read, J.A.,Brandon, N.J.,Nairn, A.C.,Lombroso, P.J.,Kack, H.,Ellman, J.A. X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors. J. Med. Chem., 60:9299-9319, 2017 Cited by PubMed: 29116812DOI: 10.1021/acs.jmedchem.7b01292 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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