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5OW1

X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors

Functional Information from GO Data
ChainGOidnamespacecontents
A0004725molecular_functionprotein tyrosine phosphatase activity
A0006470biological_processprotein dephosphorylation
A0016311biological_processdephosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues12
Detailsbinding site for residue AY8 A 601
ChainResidue
ATYR304
AHOH733
AHOH743
AHOH755
ATRP435
ALYS439
AALA474
AARG478
AGLN516
ATHR517
AGLN520
AHOH714

Functional Information from PROSITE/UniProt
site_idPS00383
Number of Residues11
DetailsTYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRTG
ChainResidueDetails
AVAL470-GLY480

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044
ChainResidueDetails
ACYS472

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASP437
AGLN516

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING:
ChainResidueDetails
ACYS472

227344

PDB entries from 2024-11-13

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