5OVF
Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor compound 17
Summary for 5OVF
Entry DOI | 10.2210/pdb5ovf/pdb |
Related | 2II0 5OVD 5OVE 5OVG 5OVH 5OVI |
Descriptor | Son of sevenless homolog 1, 6,7-dimethoxy-2-methyl-~{N}-[(1~{R})-1-[3-(1~{H}-pyrazol-4-yl)phenyl]ethyl]quinazolin-4-amine, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | signaling protein, guanine exchange factor, gef, inhibitor, sos1 |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 57828.15 |
Authors | Hillig, R.C.,Sautier, B.,Schroeder, J.,Moosmayer, D.,Hilpmann, A.,Stegmann, C.M.,Briem, H.,Boemer, U.,Weiske, J.,Badock, V.,Petersen, K.,Kahmann, J.,Wegener, D.,Bohnke, N.,Eis, K.,Graham, K.,Wortmann, L.,von Nussbaum, F.,Bader, B. (deposition date: 2017-08-28, release date: 2019-02-06, Last modification date: 2024-05-01) |
Primary citation | Hillig, R.C.,Sautier, B.,Schroeder, J.,Moosmayer, D.,Hilpmann, A.,Stegmann, C.M.,Werbeck, N.D.,Briem, H.,Boemer, U.,Weiske, J.,Badock, V.,Mastouri, J.,Petersen, K.,Siemeister, G.,Kahmann, J.D.,Wegener, D.,Bohnke, N.,Eis, K.,Graham, K.,Wortmann, L.,von Nussbaum, F.,Bader, B. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc. Natl. Acad. Sci. U.S.A., 116:2551-2560, 2019 Cited by PubMed: 30683722DOI: 10.1073/pnas.1812963116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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