5OSY
Human Decapping Scavenger enzyme (hDcpS) in complex with m7G(5'S)ppSp(5'S)G mRNA 5' cap analog
Summary for 5OSY
Entry DOI | 10.2210/pdb5osy/pdb |
Descriptor | m7GpppX diphosphatase, [(2~{S},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-[[[(2~{S},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-oxidanyl-phosphoryl]oxy-sulfanyl-phosphoryl]oxy-phosphinic acid, GLYCEROL, ... (4 entities in total) |
Functional Keywords | protein-ligand complex, decapping, dcps, m7g(5's)ppsp(5's)g, phosphorothiolate, mrna 5' cap analog, mrna turnover, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q96C86 |
Total number of polymer chains | 2 |
Total formula weight | 71946.97 |
Authors | Warminski, M.,Nowak, E.,Wojtczak, B.A.,Fac-Dabrowska, K.,Kubacka, D.,Nowicka, A.,Sikorski, P.J.,Kowalska, J.,Jemielity, J.,Nowotny, M. (deposition date: 2017-08-18, release date: 2018-05-02, Last modification date: 2024-01-17) |
Primary citation | Wojtczak, B.A.,Sikorski, P.J.,Fac-Dabrowska, K.,Nowicka, A.,Warminski, M.,Kubacka, D.,Nowak, E.,Nowotny, M.,Kowalska, J.,Jemielity, J. 5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes. J. Am. Chem. Soc., 140:5987-5999, 2018 Cited by PubMed: 29676910DOI: 10.1021/jacs.8b02597 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
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