5NXC

LIM Domain Kinase 1 (LIMK1) In Complex With PF-00477736

Summary for 5NXC

• Entry DOI: 10.2210/pdb5nxc/pdb
• Descriptor: LIM domain kinase 1, (2~{R})-2-azanyl-2-cyclohexyl-~{N}-[2-(1-methylpyrazol-4-yl)-9-oxidanylidene-3,10,11-triazatricyclo[6.4.1.0^{4,13}]trideca-1,4,6,8(13),11-pentaen-6-yl]ethanamide (3 entities in total)
• Functional Keywords: kinase actin cytoskeleton inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P53667
• Total number of polymer chains: 1
• Total formula weight: 36414.25

Authors

Mathea, S.,Salah, E.,Pike, A.C.W.,Bushell, S.,Carpenter, E.P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N.,Knapp, S. (deposition date: 2017-05-10, release date: 2017-05-24, Last modification date: 2024-01-17)

• Primary citation: Mathea, S.,Salah, E.,Pike, A.C.W.,Bushell, S.,Carpenter, E.P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N.,Knapp, S.; LIM Domain Kinase (LIMK1) In Complex With PF-00477736; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.25 Å)