5NQW
IgE-Fc in complex with single domain antibody 026
Summary for 5NQW
Entry DOI | 10.2210/pdb5nqw/pdb |
Descriptor | Immunoglobulin heavy constant epsilon, 026, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | ige-fc, nanobody, vhh, allergy, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 79828.77 |
Authors | Laursen, N.S.,Jabs, F.,Spillner, E.,Andersen, G.R. (deposition date: 2017-04-21, release date: 2018-01-17, Last modification date: 2024-01-17) |
Primary citation | Jabs, F.,Plum, M.,Laursen, N.S.,Jensen, R.K.,Molgaard, B.,Miehe, M.,Mandolesi, M.,Rauber, M.M.,Pfutzner, W.,Jakob, T.,Mobs, C.,Andersen, G.R.,Spillner, E. Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts Fc epsilon RI interaction. Nat Commun, 9:7-7, 2018 Cited by PubMed: 29295972DOI: 10.1038/s41467-017-02312-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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