5NO1
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ407 (compound 5g)
Summary for 5NO1
Entry DOI | 10.2210/pdb5no1/pdb |
Descriptor | Integrase, HEXANE-1,6-DIOL, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), ... (11 entities in total) |
Functional Keywords | hiv, pfv, prototype foamy virus, integrase, strand transfer, insti, tetramer intasome, integration, inhibitor, drug, viral protein |
Biological source | Human spumaretrovirus (SFVcpz(hu)) More |
Cellular location | Integrase: Virion . Protease/Reverse transcriptase/ribonuclease H: Host nucleus : P14350 |
Total number of polymer chains | 4 |
Total formula weight | 102164.76 |
Authors | Pye, V.E.,Cherepanov, P. (deposition date: 2017-04-10, release date: 2017-08-02, Last modification date: 2024-01-17) |
Primary citation | Zhao, X.Z.,Smith, S.J.,Maskell, D.P.,Metifiot, M.,Pye, V.E.,Fesen, K.,Marchand, C.,Pommier, Y.,Cherepanov, P.,Hughes, S.H.,Burke, T.R. Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors. J. Med. Chem., 60:7315-7332, 2017 Cited by PubMed: 28737946DOI: 10.1021/acs.jmedchem.7b00596 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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