5NJD
Structure of Interleukin 23 in complex with Briakinumab FAb
Summary for 5NJD
Entry DOI | 10.2210/pdb5njd/pdb |
Descriptor | Interleukin-12 subunit beta, Interleukin-23 subunit alpha, Briakinumab FAb Light chain, ... (6 entities in total) |
Functional Keywords | antagonist, antibody, extracellular region, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 24 |
Total formula weight | 701055.70 |
Authors | Bloch, Y.,Savvides, S.N. (deposition date: 2017-03-28, release date: 2018-01-03, Last modification date: 2024-01-17) |
Primary citation | Bloch, Y.,Bouchareychas, L.,Merceron, R.,Skladanowska, K.,Van den Bossche, L.,Detry, S.,Govindarajan, S.,Elewaut, D.,Haerynck, F.,Dullaers, M.,Adamopoulos, I.E.,Savvides, S.N. Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12R beta 1. Immunity, 48:45-58.e6, 2018 Cited by PubMed: 29287995DOI: 10.1016/j.immuni.2017.12.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.9 Å) |
Structure validation
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