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5NJD

Structure of Interleukin 23 in complex with Briakinumab FAb

Summary for 5NJD
Entry DOI10.2210/pdb5njd/pdb
DescriptorInterleukin-12 subunit beta, Interleukin-23 subunit alpha, Briakinumab FAb Light chain, ... (6 entities in total)
Functional Keywordsantagonist, antibody, extracellular region, immune system
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains24
Total formula weight701055.70
Authors
Bloch, Y.,Savvides, S.N. (deposition date: 2017-03-28, release date: 2018-01-03, Last modification date: 2024-01-17)
Primary citationBloch, Y.,Bouchareychas, L.,Merceron, R.,Skladanowska, K.,Van den Bossche, L.,Detry, S.,Govindarajan, S.,Elewaut, D.,Haerynck, F.,Dullaers, M.,Adamopoulos, I.E.,Savvides, S.N.
Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12R beta 1.
Immunity, 48:45-58.e6, 2018
Cited by
PubMed: 29287995
DOI: 10.1016/j.immuni.2017.12.008
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.9 Å)
Structure validation

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