5NJD
Structure of Interleukin 23 in complex with Briakinumab FAb
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, E, G, I... | Interleukin-12 subunit beta | polymer | 328 | 37212.9 | 6 | UniProt (P29460) Pfam (PF10420) In PDB | Homo sapiens (Human) | IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit,CLMF p40,IL-12 subunit p40,NK cell stimulatory factor chain 2,NKSF2 |
2 | B, D, F, H, J... | Interleukin-23 subunit alpha | polymer | 198 | 21865.9 | 6 | UniProt (Q9NPF7) Pfam (PF16649) In PDB | Homo sapiens (Human) | IL-23-A,Interleukin-23 subunit p19,IL-23p19 |
3 | M, O, Q, S, U... | Briakinumab FAb Light chain | polymer | 245 | 25925.2 | 6 | Homo sapiens (Human) | ||
4 | N, P, R, T, V... | Briakinumab FAb Heavy chain | polymer | 289 | 30719.7 | 6 | Homo sapiens (Human) | ||
5 | a, b, c, d, Y... | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 6 | In PDB GlyTouCan (G22768VO) | |||
6 | M, O, Q, R, S... | SULFATE ION | non-polymer | 96.1 | 13 | Chemie (SO4) |
Sequence modifications
B, D, F, H, J, L: 1 - 189 (UniProt: Q9NPF7)
PDB | External Database | Details |
---|---|---|
Gly 190 | - | expression tag |
Thr 191 | - | expression tag |
Lys 192 | - | expression tag |
His 193 | - | expression tag |
His 194 | - | expression tag |
His 195 | - | expression tag |
His 196 | - | expression tag |
His 197 | - | expression tag |
His 198 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 24 |
Total formula weight | 694341.9 | |
Branched | Number of molecules | 6 |
Total formula weight | 5464.9 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 1248.8 | |
All* | Total formula weight | 701055.7 |