5NJD

Structure of Interleukin 23 in complex with Briakinumab FAb

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I... (A, C, E, G, I...)	Interleukin-12 subunit beta	polymer	328	37212.9	6	UniProt (P29460) Pfam (PF10420)	Homo sapiens (Human)	IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit,CLMF p40,IL-12 subunit p40,NK cell stimulatory factor chain 2,NKSF2
2	B, D, F, H, J... (B, D, F, H, J...)	Interleukin-23 subunit alpha	polymer	198	21865.9	6	UniProt (Q9NPF7) Pfam (PF16649)	Homo sapiens (Human)	IL-23-A,Interleukin-23 subunit p19,IL-23p19
3	M, O, Q, S, U... (M, O, Q, S, U...)	Briakinumab FAb Light chain	polymer	245	25925.2	6		Homo sapiens (Human)
4	N, P, R, T, V... (N, P, R, T, V...)	Briakinumab FAb Heavy chain	polymer	289	30719.7	6		Homo sapiens (Human)
5	AA, BA, CA, DA, Y... (a, b, c, d, Y...)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	6	In PDB GlyTouCan (G22768VO)
6	EA, FA, GA, HA, IA... (M, O, Q, R, S...)	SULFATE ION	non-polymer		96.1	13	Chemie (SO4)

Sequence modifications

B, D, F, H, J, L: 1 - 189 (UniProt: Q9NPF7)

PDB	External Database	Details
Gly 190	-	expression tag
Thr 191	-	expression tag
Lys 192	-	expression tag
His 193	-	expression tag
His 194	-	expression tag
His 195	-	expression tag
His 196	-	expression tag
His 197	-	expression tag
His 198	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	24
	Total formula weight	694341.9
Branched	Number of molecules	6
	Total formula weight	5464.9
Non-Polymers*	Number of molecules	13
	Total formula weight	1248.8
All*	Total formula weight	701055.7

*Water molecules are not included.