5NJD

Structure of Interleukin 23 in complex with Briakinumab FAb

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004896	molecular_function	cytokine receptor activity
A	0016020	cellular_component	membrane
B	0005125	molecular_function	cytokine activity
B	0005576	cellular_component	extracellular region
B	0006955	biological_process	immune response
C	0004896	molecular_function	cytokine receptor activity
C	0016020	cellular_component	membrane
D	0005125	molecular_function	cytokine activity
D	0005576	cellular_component	extracellular region
D	0006955	biological_process	immune response
E	0004896	molecular_function	cytokine receptor activity
E	0016020	cellular_component	membrane
F	0005125	molecular_function	cytokine activity
F	0005576	cellular_component	extracellular region
F	0006955	biological_process	immune response
G	0004896	molecular_function	cytokine receptor activity
G	0016020	cellular_component	membrane
H	0005125	molecular_function	cytokine activity
H	0005576	cellular_component	extracellular region
H	0006955	biological_process	immune response
I	0004896	molecular_function	cytokine receptor activity
I	0016020	cellular_component	membrane
J	0005125	molecular_function	cytokine activity
J	0005576	cellular_component	extracellular region
J	0006955	biological_process	immune response
K	0004896	molecular_function	cytokine receptor activity
K	0016020	cellular_component	membrane
L	0005125	molecular_function	cytokine activity
L	0005576	cellular_component	extracellular region
L	0006955	biological_process	immune response

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH

Chain	Residue	Details
M	TYR196-HIS202
N	TYR196-HIS202

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site_id	PS01354
Number of Residues	43
Details	HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. IkPDPPknLqlkplknsrq.VevsWeyPdTWstphsyFsLtFcV

Chain	Residue	Details
A	ILE233-VAL275

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN135
C	ASN135
E	ASN135
G	ASN135
I	ASN135
K	ASN135

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site_id	SWS_FT_FI2
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10899108

Chain	Residue	Details
A	ASN222
C	ASN222
E	ASN222
G	ASN222
I	ASN222
K	ASN222

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site_id	SWS_FT_FI3
Number of Residues	6
Details	CARBOHYD: C-linked (Man) tryptophan => ECO:0000269|PubMed:10207176

Chain	Residue	Details
A	TRP319
C	TRP319
E	TRP319
G	TRP319
I	TRP319
K	TRP319

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