5NCJ

GriE in complex with manganese, succinate and (2S,4R)-5-hydroxyleucine

Summary for 5NCJ

Entry DOI	10.2210/pdb5ncj/pdb
Descriptor	Leucine hydroxylase, MANGANESE (II) ION, SUCCINIC ACID, ... (5 entities in total)
Functional Keywords	fe(ii)/alpha-ketoglutarate dependent dioxygenase, hydroxylase, non-heme iron protein, leucine hydroxylase, 5-hydroxyleucine, (2s4r)-5-hydroxyleucine, 4-methyl-proline, griselimycin, methyl-griselimycin, oxidoreductase
Biological source	Streptomyces sp. DSM 40835
Total number of polymer chains	2
Total formula weight	60369.38
Authors	Lukat, P.,Blankenfeldt, W.,Mueller, R. (deposition date: 2017-03-05, release date: 2017-10-04, Last modification date: 2024-01-17)
Primary citation	Lukat, P.,Katsuyama, Y.,Wenzel, S.,Binz, T.,Konig, C.,Blankenfeldt, W.,Bronstrup, M.,Muller, R. Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity. Chem Sci, 8:7521-7527, 2017 Cited by PubMed: 29163906 DOI: 10.1039/c7sc02622f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.529 Å)

Structure validation