5MU8
HUMAN TNF-ALPHA IN COMPLEX WITH JNJ525
Summary for 5MU8
Entry DOI | 10.2210/pdb5mu8/pdb |
Descriptor | Tumor necrosis factor, ~{N}4-(phenylmethyl)-~{N}4-[2-[3-(2-piperazin-1-ylpyrimidin-5-yl)phenyl]phenyl]pyrimidine-2,4-diamine (2 entities in total) |
Functional Keywords | tumor necrosis factor alpha, proteros biostructures gmbh, cytokine |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 48 |
Total formula weight | 867173.44 |
Authors | Blevitt, J.M.,Hack, M.D.,Herman, K.L.,Jackson, P.F.,Krawczuk, P.J.,Lebsack, A.D.,Liu, A.X.,Mirzadegan, T.,Nelen, M.I.,Patrick, A.P.,Steinbacher, S.,Milla, M.E.,Lumb, K.J. (deposition date: 2017-01-12, release date: 2017-03-29, Last modification date: 2019-02-20) |
Primary citation | Blevitt, J.M.,Hack, M.D.,Herman, K.L.,Jackson, P.F.,Krawczuk, P.J.,Lebsack, A.D.,Liu, A.X.,Mirzadegan, T.,Nelen, M.I.,Patrick, A.N.,Steinbacher, S.,Milla, M.E.,Lumb, K.J. Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction. J. Med. Chem., 60:3511-3517, 2017 Cited by PubMed: 28300404DOI: 10.1021/acs.jmedchem.6b01836 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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