Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5MU8

HUMAN TNF-ALPHA IN COMPLEX WITH JNJ525

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005164	molecular_function	tumor necrosis factor receptor binding
A	0006955	biological_process	immune response
A	0016020	cellular_component	membrane
B	0005164	molecular_function	tumor necrosis factor receptor binding
B	0006955	biological_process	immune response
B	0016020	cellular_component	membrane
C	0005164	molecular_function	tumor necrosis factor receptor binding
C	0006955	biological_process	immune response
C	0016020	cellular_component	membrane
D	0005164	molecular_function	tumor necrosis factor receptor binding
D	0006955	biological_process	immune response
D	0016020	cellular_component	membrane
F	0005164	molecular_function	tumor necrosis factor receptor binding
F	0006955	biological_process	immune response
F	0016020	cellular_component	membrane
G	0005164	molecular_function	tumor necrosis factor receptor binding
G	0006955	biological_process	immune response
G	0016020	cellular_component	membrane
H	0005164	molecular_function	tumor necrosis factor receptor binding
H	0006955	biological_process	immune response
H	0016020	cellular_component	membrane
I	0005164	molecular_function	tumor necrosis factor receptor binding
I	0006955	biological_process	immune response
I	0016020	cellular_component	membrane
J	0005164	molecular_function	tumor necrosis factor receptor binding
J	0006955	biological_process	immune response
J	0016020	cellular_component	membrane
K	0005164	molecular_function	tumor necrosis factor receptor binding
K	0006955	biological_process	immune response
K	0016020	cellular_component	membrane
L	0005164	molecular_function	tumor necrosis factor receptor binding
L	0006955	biological_process	immune response
L	0016020	cellular_component	membrane
M	0005164	molecular_function	tumor necrosis factor receptor binding
M	0006955	biological_process	immune response
M	0016020	cellular_component	membrane
N	0005164	molecular_function	tumor necrosis factor receptor binding
N	0006955	biological_process	immune response
N	0016020	cellular_component	membrane
O	0005164	molecular_function	tumor necrosis factor receptor binding
O	0006955	biological_process	immune response
O	0016020	cellular_component	membrane
P	0005164	molecular_function	tumor necrosis factor receptor binding
P	0006955	biological_process	immune response
P	0016020	cellular_component	membrane
Q	0005164	molecular_function	tumor necrosis factor receptor binding
Q	0006955	biological_process	immune response
Q	0016020	cellular_component	membrane
R	0005164	molecular_function	tumor necrosis factor receptor binding
R	0006955	biological_process	immune response
R	0016020	cellular_component	membrane
S	0005164	molecular_function	tumor necrosis factor receptor binding
S	0006955	biological_process	immune response
S	0016020	cellular_component	membrane
T	0005164	molecular_function	tumor necrosis factor receptor binding
T	0006955	biological_process	immune response
T	0016020	cellular_component	membrane
U	0005164	molecular_function	tumor necrosis factor receptor binding
U	0006955	biological_process	immune response
U	0016020	cellular_component	membrane
V	0005164	molecular_function	tumor necrosis factor receptor binding
V	0006955	biological_process	immune response
V	0016020	cellular_component	membrane
W	0005164	molecular_function	tumor necrosis factor receptor binding
W	0006955	biological_process	immune response
W	0016020	cellular_component	membrane
X	0005164	molecular_function	tumor necrosis factor receptor binding
X	0006955	biological_process	immune response
X	0016020	cellular_component	membrane
Y	0005164	molecular_function	tumor necrosis factor receptor binding
Y	0006955	biological_process	immune response
Y	0016020	cellular_component	membrane
Z	0005164	molecular_function	tumor necrosis factor receptor binding
Z	0006955	biological_process	immune response
Z	0016020	cellular_component	membrane
a	0005164	molecular_function	tumor necrosis factor receptor binding
a	0006955	biological_process	immune response
a	0016020	cellular_component	membrane
b	0005164	molecular_function	tumor necrosis factor receptor binding
b	0006955	biological_process	immune response
b	0016020	cellular_component	membrane
c	0005164	molecular_function	tumor necrosis factor receptor binding
c	0006955	biological_process	immune response
c	0016020	cellular_component	membrane
d	0005164	molecular_function	tumor necrosis factor receptor binding
d	0006955	biological_process	immune response
d	0016020	cellular_component	membrane
e	0005164	molecular_function	tumor necrosis factor receptor binding
e	0006955	biological_process	immune response
e	0016020	cellular_component	membrane
f	0005164	molecular_function	tumor necrosis factor receptor binding
f	0006955	biological_process	immune response
f	0016020	cellular_component	membrane
g	0005164	molecular_function	tumor necrosis factor receptor binding
g	0006955	biological_process	immune response
g	0016020	cellular_component	membrane
h	0005164	molecular_function	tumor necrosis factor receptor binding
h	0006955	biological_process	immune response
h	0016020	cellular_component	membrane
i	0005164	molecular_function	tumor necrosis factor receptor binding
i	0006955	biological_process	immune response
i	0016020	cellular_component	membrane
j	0005164	molecular_function	tumor necrosis factor receptor binding
j	0006955	biological_process	immune response
j	0016020	cellular_component	membrane
k	0005164	molecular_function	tumor necrosis factor receptor binding
k	0006955	biological_process	immune response
k	0016020	cellular_component	membrane
l	0005164	molecular_function	tumor necrosis factor receptor binding
l	0006955	biological_process	immune response
l	0016020	cellular_component	membrane
m	0005164	molecular_function	tumor necrosis factor receptor binding
m	0006955	biological_process	immune response
m	0016020	cellular_component	membrane
n	0005164	molecular_function	tumor necrosis factor receptor binding
n	0006955	biological_process	immune response
n	0016020	cellular_component	membrane
o	0005164	molecular_function	tumor necrosis factor receptor binding
o	0006955	biological_process	immune response
o	0016020	cellular_component	membrane
p	0005164	molecular_function	tumor necrosis factor receptor binding
p	0006955	biological_process	immune response
p	0016020	cellular_component	membrane
q	0005164	molecular_function	tumor necrosis factor receptor binding
q	0006955	biological_process	immune response
q	0016020	cellular_component	membrane
r	0005164	molecular_function	tumor necrosis factor receptor binding
r	0006955	biological_process	immune response
r	0016020	cellular_component	membrane
s	0005164	molecular_function	tumor necrosis factor receptor binding
s	0006955	biological_process	immune response
s	0016020	cellular_component	membrane
t	0005164	molecular_function	tumor necrosis factor receptor binding
t	0006955	biological_process	immune response
t	0016020	cellular_component	membrane
u	0005164	molecular_function	tumor necrosis factor receptor binding
u	0006955	biological_process	immune response
u	0016020	cellular_component	membrane
v	0005164	molecular_function	tumor necrosis factor receptor binding
v	0006955	biological_process	immune response
v	0016020	cellular_component	membrane
w	0005164	molecular_function	tumor necrosis factor receptor binding
w	0006955	biological_process	immune response
w	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue JNI A 201

Chain	Residue
A	LEU57
B	LEU57
B	TYR119
B	GLY121
B	GLY122
C	JNI201
A	SER60
A	TYR119
A	LEU120
A	GLY121
A	GLY122
A	TYR151
A	ILE155
A	JNI202

site_id	AC2
Number of Residues	5
Details	binding site for residue JNI A 202

Chain	Residue
A	HIS15
A	JNI201
C	JNI201
C	JNI202
D	JNI201

site_id	AC3
Number of Residues	8
Details	binding site for residue JNI C 201

Chain	Residue
A	JNI201
A	JNI202
B	LEU55
B	LEU157
C	TYR119
D	SER60
D	GLY121
D	JNI201

site_id	AC4
Number of Residues	8
Details	binding site for residue JNI C 202

Chain	Residue
A	SER9
A	LEU36
A	JNI202
C	HIS15
C	ASN34
C	LEU36
C	TYR59
C	SER147

site_id	AC5
Number of Residues	4
Details	binding site for residue JNI D 201

Chain	Residue
A	JNI202
C	JNI201
D	LEU57
D	ALA156

site_id	AC6
Number of Residues	13
Details	binding site for residue JNI F 201

Chain	Residue
F	LEU57
F	SER60
F	GLN61
F	TYR119
F	LEU120
F	GLY121
F	GLY122
F	TYR151
F	JNI202
G	TYR119
G	GLY121
H	JNI202
I	LEU157

site_id	AC7
Number of Residues	4
Details	binding site for residue JNI F 202

Chain	Residue
F	HIS15
F	JNI201
H	JNI201
H	JNI202

site_id	AC8
Number of Residues	5
Details	binding site for residue JNI H 201

Chain	Residue
F	JNI202
H	TYR151
H	ILE155
H	JNI202
I	TYR59

site_id	AC9
Number of Residues	8
Details	binding site for residue JNI H 202

Chain	Residue
F	JNI201
F	JNI202
G	LEU55
G	LEU157
H	TYR119
H	JNI201
I	TYR119
I	GLY121

site_id	AD1
Number of Residues	15
Details	binding site for residue JNI J 201

Chain	Residue
J	LEU57
J	ILE58
J	TYR59
J	SER60
J	GLN61
J	TYR119
J	LEU120
J	GLY121
J	GLY122
J	TYR151
J	JNI202
K	LEU57
K	TYR119
K	GLY121
L	JNI201

site_id	AD2
Number of Residues	3
Details	binding site for residue JNI J 202

Chain	Residue
J	HIS15
J	JNI201
L	JNI201

site_id	AD3
Number of Residues	10
Details	binding site for residue JNI L 201

Chain	Residue
J	JNI201
J	JNI202
L	TYR119
L	LEU120
L	GLY121
M	TYR59
M	TYR119
M	LEU120
M	GLY121
M	JNI201

site_id	AD4
Number of Residues	6
Details	binding site for residue JNI M 201

Chain	Residue
L	JNI201
M	LYS11
M	LEU57
M	LEU157
L	GLY121
L	TYR151

site_id	AD5
Number of Residues	14
Details	binding site for residue JNI N 201

Chain	Residue
N	LEU57
N	TYR59
N	SER60
N	GLN61
N	TYR119
N	LEU120
N	GLY121
N	GLY122
N	TYR151
O	LEU57
O	TYR119
O	GLY121
O	GLY122
P	JNI201

site_id	AD6
Number of Residues	4
Details	binding site for residue JNI P 201

Chain	Residue
N	JNI201
P	ILE155
P	JNI202
Q	JNI201

site_id	AD7
Number of Residues	7
Details	binding site for residue JNI P 202

Chain	Residue
O	LEU157
P	TYR119
P	JNI201
Q	TYR119
Q	LEU120
Q	GLY121
Q	JNI201

site_id	AD8
Number of Residues	7
Details	binding site for residue JNI Q 201

Chain	Residue
P	LEU57
P	LEU157
P	JNI201
P	JNI202
Q	LYS11
Q	LEU57
Q	ALA156

site_id	AD9
Number of Residues	8
Details	binding site for residue JNI R 201

Chain	Residue
R	LEU57
R	SER60
R	GLN61
R	TYR119
R	GLY121
R	TYR151
S	TYR119
S	GLY121

site_id	AE1
Number of Residues	6
Details	binding site for residue JNI U 201

Chain	Residue
T	GLY121
T	TYR151
U	LYS11
U	LEU57
U	TYR59
U	ALA156

site_id	AE2
Number of Residues	10
Details	binding site for residue JNI V 201

Chain	Residue
V	LEU57
V	SER60
V	GLN61
V	TYR119
V	LEU120
V	TYR151
V	JNI202
W	TYR119
W	GLY121
X	JNI202

site_id	AE3
Number of Residues	4
Details	binding site for residue JNI V 202

Chain	Residue
V	HIS15
V	JNI201
X	JNI201
X	JNI202

site_id	AE4
Number of Residues	9
Details	binding site for residue JNI X 201

Chain	Residue
V	JNI202
X	LEU57
X	GLY121
X	TYR151
X	JNI202
Y	LYS11
Y	LEU57
Y	TYR59
Y	LEU157

site_id	AE5
Number of Residues	8
Details	binding site for residue JNI X 202

Chain	Residue
V	JNI201
V	JNI202
W	LEU55
W	LEU157
X	TYR119
X	JNI201
Y	TYR119
Y	GLY121

site_id	AE6
Number of Residues	13
Details	binding site for residue JNI Z 201

Chain	Residue
Z	LEU57
Z	SER60
Z	GLN61
Z	TYR119
Z	LEU120
Z	GLY121
Z	TYR151
Z	JNI202
a	LEU57
a	TYR119
a	GLY121
a	GLY122
b	JNI202

site_id	AE7
Number of Residues	2
Details	binding site for residue JNI Z 202

Chain	Residue
Z	JNI201
b	JNI201

site_id	AE8
Number of Residues	10
Details	binding site for residue JNI b 201

Chain	Residue
Z	JNI202
b	LEU57
b	GLY121
b	TYR151
b	JNI202
c	LYS11
c	LEU57
c	TYR59
c	ALA156
c	LEU157

site_id	AE9
Number of Residues	6
Details	binding site for residue JNI b 202

Chain	Residue
Z	JNI201
a	LEU55
a	LEU157
b	TYR119
b	JNI201
c	TYR119

site_id	AF1
Number of Residues	10
Details	binding site for residue JNI d 201

Chain	Residue
d	LEU57
d	TYR59
d	SER60
d	GLN61
d	TYR119
d	LEU120
d	TYR151
e	TYR119
e	GLY121
f	JNI201

site_id	AF2
Number of Residues	4
Details	binding site for residue JNI f 201

Chain	Residue
d	HIS15
d	JNI201
f	ILE155
f	JNI202

site_id	AF3
Number of Residues	11
Details	binding site for residue JNI f 202

Chain	Residue
d	SER9
d	ASP10
d	VAL13
d	ASN39
d	ILE155
f	PRO8
f	SER9
f	HIS15
f	ALA33
f	ASN34
f	JNI201

site_id	AF4
Number of Residues	10
Details	binding site for residue JNI h 201

Chain	Residue
h	LEU57
h	SER60
h	TYR119
h	LEU120
h	TYR151
i	LEU57
i	TYR119
i	GLY121
j	JNI202
k	LYS11

site_id	AF5
Number of Residues	1
Details	binding site for residue JNI h 202

Chain	Residue
j	JNI201

site_id	AF6
Number of Residues	6
Details	binding site for residue JNI j 201

Chain	Residue
h	JNI202
j	GLY121
j	TYR151
j	JNI202
k	LEU57
k	LEU157

site_id	AF7
Number of Residues	6
Details	binding site for residue JNI j 202

Chain	Residue
h	JNI201
i	LEU55
i	LEU157
j	TYR119
j	JNI201
k	TYR119

site_id	AF8
Number of Residues	11
Details	binding site for residue JNI l 201

Chain	Residue
l	LEU57
l	SER60
l	GLN61
l	PRO117
l	TYR119
l	LEU120
l	TYR151
m	TYR119
m	GLY121
n	JNI201
n	JNI202

site_id	AF9
Number of Residues	2
Details	binding site for residue JNI n 201

Chain	Residue
l	JNI201
o	JNI201

site_id	AG1
Number of Residues	6
Details	binding site for residue JNI n 202

Chain	Residue
l	JNI201
m	LEU55
m	LEU157
n	TYR119
o	TYR119
o	JNI201

site_id	AG2
Number of Residues	8
Details	binding site for residue JNI o 201

Chain	Residue
n	TYR59
n	GLY121
n	JNI201
n	JNI202
o	LYS11
o	LEU57
o	ALA156
o	LEU157

site_id	AG3
Number of Residues	10
Details	binding site for residue JNI p 201

Chain	Residue
p	LEU57
p	TYR59
p	GLN61
p	TYR119
p	LEU120
p	TYR151
p	JNI202
q	TYR119
q	GLY121
r	JNI202

site_id	AG4
Number of Residues	8
Details	binding site for residue JNI p 202

Chain	Residue
p	HIS15
p	JNI201
r	SER9
r	VAL13
r	HIS15
r	ILE155
r	JNI201
r	JNI202

site_id	AG5
Number of Residues	7
Details	binding site for residue JNI r 201

Chain	Residue
p	JNI202
r	SER60
r	GLY121
r	TYR151
r	ILE155
r	JNI202
s	TYR59

site_id	AG6
Number of Residues	7
Details	binding site for residue JNI r 202

Chain	Residue
p	JNI201
p	JNI202
q	LEU55
q	LEU157
r	TYR119
r	JNI201
s	TYR119

site_id	AG7
Number of Residues	12
Details	binding site for residue JNI t 201

Chain	Residue
t	LEU57
t	SER60
t	TYR119
t	LEU120
t	GLY121
t	GLY122
t	TYR151
t	JNI202
u	LEU57
u	TYR119
u	GLY121
w	LEU157

site_id	AG8
Number of Residues	5
Details	binding site for residue JNI t 202

Chain	Residue
t	HIS15
t	JNI201
v	SER9
v	JNI201
v	JNI202

site_id	AG9
Number of Residues	7
Details	binding site for residue JNI v 201

Chain	Residue
t	JNI202
v	TYR119
v	GLY121
v	TYR151
v	JNI202
w	LEU57
w	TYR59

site_id	AH1
Number of Residues	6
Details	binding site for residue JNI v 202

Chain	Residue
t	JNI202
u	LEU55
u	LEU157
v	TYR119
v	JNI201
w	TYR119

site_id	AH2
Number of Residues	21
Details	binding site for Di-peptide GLU s 23 and ARG D 32

Chain	Residue
C	VAL91
D	GLN21
D	ALA22
D	GLY24
D	GLN25
D	ASN30
D	ARG31
D	ALA33
D	ASN34
D	ALA35
D	SER147
D	SER147
s	PRO20
s	ALA22
s	GLY24
s	GLN25
s	ASN30
s	ARG31
s	ALA33
s	ASN34
s	ALA35

Functional Information from PROSITE/UniProt

site_id	PS00251
Number of Residues	17
Details	THD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LvVPsEGLYLIysQVlF

Chain	Residue	Details
A	LEU48-PHE64

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2175
Details	Domain: {"description":"THD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01387","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)