5MU8
HUMAN TNF-ALPHA IN COMPLEX WITH JNJ525
Functional Information from GO Data
Chain | GOid | namespace | contents |
a | 0005164 | molecular_function | tumor necrosis factor receptor binding |
a | 0006955 | biological_process | immune response |
a | 0016020 | cellular_component | membrane |
A | 0005164 | molecular_function | tumor necrosis factor receptor binding |
A | 0006955 | biological_process | immune response |
A | 0016020 | cellular_component | membrane |
b | 0005164 | molecular_function | tumor necrosis factor receptor binding |
b | 0006955 | biological_process | immune response |
b | 0016020 | cellular_component | membrane |
B | 0005164 | molecular_function | tumor necrosis factor receptor binding |
B | 0006955 | biological_process | immune response |
B | 0016020 | cellular_component | membrane |
c | 0005164 | molecular_function | tumor necrosis factor receptor binding |
c | 0006955 | biological_process | immune response |
c | 0016020 | cellular_component | membrane |
C | 0005164 | molecular_function | tumor necrosis factor receptor binding |
C | 0006955 | biological_process | immune response |
C | 0016020 | cellular_component | membrane |
d | 0005164 | molecular_function | tumor necrosis factor receptor binding |
d | 0006955 | biological_process | immune response |
d | 0016020 | cellular_component | membrane |
D | 0005164 | molecular_function | tumor necrosis factor receptor binding |
D | 0006955 | biological_process | immune response |
D | 0016020 | cellular_component | membrane |
e | 0005164 | molecular_function | tumor necrosis factor receptor binding |
e | 0006955 | biological_process | immune response |
e | 0016020 | cellular_component | membrane |
f | 0005164 | molecular_function | tumor necrosis factor receptor binding |
f | 0006955 | biological_process | immune response |
f | 0016020 | cellular_component | membrane |
F | 0005164 | molecular_function | tumor necrosis factor receptor binding |
F | 0006955 | biological_process | immune response |
F | 0016020 | cellular_component | membrane |
g | 0005164 | molecular_function | tumor necrosis factor receptor binding |
g | 0006955 | biological_process | immune response |
g | 0016020 | cellular_component | membrane |
G | 0005164 | molecular_function | tumor necrosis factor receptor binding |
G | 0006955 | biological_process | immune response |
G | 0016020 | cellular_component | membrane |
h | 0005164 | molecular_function | tumor necrosis factor receptor binding |
h | 0006955 | biological_process | immune response |
h | 0016020 | cellular_component | membrane |
H | 0005164 | molecular_function | tumor necrosis factor receptor binding |
H | 0006955 | biological_process | immune response |
H | 0016020 | cellular_component | membrane |
i | 0005164 | molecular_function | tumor necrosis factor receptor binding |
i | 0006955 | biological_process | immune response |
i | 0016020 | cellular_component | membrane |
I | 0005164 | molecular_function | tumor necrosis factor receptor binding |
I | 0006955 | biological_process | immune response |
I | 0016020 | cellular_component | membrane |
j | 0005164 | molecular_function | tumor necrosis factor receptor binding |
j | 0006955 | biological_process | immune response |
j | 0016020 | cellular_component | membrane |
J | 0005164 | molecular_function | tumor necrosis factor receptor binding |
J | 0006955 | biological_process | immune response |
J | 0016020 | cellular_component | membrane |
k | 0005164 | molecular_function | tumor necrosis factor receptor binding |
k | 0006955 | biological_process | immune response |
k | 0016020 | cellular_component | membrane |
K | 0005164 | molecular_function | tumor necrosis factor receptor binding |
K | 0006955 | biological_process | immune response |
K | 0016020 | cellular_component | membrane |
l | 0005164 | molecular_function | tumor necrosis factor receptor binding |
l | 0006955 | biological_process | immune response |
l | 0016020 | cellular_component | membrane |
L | 0005164 | molecular_function | tumor necrosis factor receptor binding |
L | 0006955 | biological_process | immune response |
L | 0016020 | cellular_component | membrane |
m | 0005164 | molecular_function | tumor necrosis factor receptor binding |
m | 0006955 | biological_process | immune response |
m | 0016020 | cellular_component | membrane |
M | 0005164 | molecular_function | tumor necrosis factor receptor binding |
M | 0006955 | biological_process | immune response |
M | 0016020 | cellular_component | membrane |
n | 0005164 | molecular_function | tumor necrosis factor receptor binding |
n | 0006955 | biological_process | immune response |
n | 0016020 | cellular_component | membrane |
N | 0005164 | molecular_function | tumor necrosis factor receptor binding |
N | 0006955 | biological_process | immune response |
N | 0016020 | cellular_component | membrane |
o | 0005164 | molecular_function | tumor necrosis factor receptor binding |
o | 0006955 | biological_process | immune response |
o | 0016020 | cellular_component | membrane |
O | 0005164 | molecular_function | tumor necrosis factor receptor binding |
O | 0006955 | biological_process | immune response |
O | 0016020 | cellular_component | membrane |
p | 0005164 | molecular_function | tumor necrosis factor receptor binding |
p | 0006955 | biological_process | immune response |
p | 0016020 | cellular_component | membrane |
P | 0005164 | molecular_function | tumor necrosis factor receptor binding |
P | 0006955 | biological_process | immune response |
P | 0016020 | cellular_component | membrane |
q | 0005164 | molecular_function | tumor necrosis factor receptor binding |
q | 0006955 | biological_process | immune response |
q | 0016020 | cellular_component | membrane |
Q | 0005164 | molecular_function | tumor necrosis factor receptor binding |
Q | 0006955 | biological_process | immune response |
Q | 0016020 | cellular_component | membrane |
r | 0005164 | molecular_function | tumor necrosis factor receptor binding |
r | 0006955 | biological_process | immune response |
r | 0016020 | cellular_component | membrane |
R | 0005164 | molecular_function | tumor necrosis factor receptor binding |
R | 0006955 | biological_process | immune response |
R | 0016020 | cellular_component | membrane |
s | 0005164 | molecular_function | tumor necrosis factor receptor binding |
s | 0006955 | biological_process | immune response |
s | 0016020 | cellular_component | membrane |
S | 0005164 | molecular_function | tumor necrosis factor receptor binding |
S | 0006955 | biological_process | immune response |
S | 0016020 | cellular_component | membrane |
t | 0005164 | molecular_function | tumor necrosis factor receptor binding |
t | 0006955 | biological_process | immune response |
t | 0016020 | cellular_component | membrane |
T | 0005164 | molecular_function | tumor necrosis factor receptor binding |
T | 0006955 | biological_process | immune response |
T | 0016020 | cellular_component | membrane |
u | 0005164 | molecular_function | tumor necrosis factor receptor binding |
u | 0006955 | biological_process | immune response |
u | 0016020 | cellular_component | membrane |
U | 0005164 | molecular_function | tumor necrosis factor receptor binding |
U | 0006955 | biological_process | immune response |
U | 0016020 | cellular_component | membrane |
v | 0005164 | molecular_function | tumor necrosis factor receptor binding |
v | 0006955 | biological_process | immune response |
v | 0016020 | cellular_component | membrane |
V | 0005164 | molecular_function | tumor necrosis factor receptor binding |
V | 0006955 | biological_process | immune response |
V | 0016020 | cellular_component | membrane |
w | 0005164 | molecular_function | tumor necrosis factor receptor binding |
w | 0006955 | biological_process | immune response |
w | 0016020 | cellular_component | membrane |
W | 0005164 | molecular_function | tumor necrosis factor receptor binding |
W | 0006955 | biological_process | immune response |
W | 0016020 | cellular_component | membrane |
X | 0005164 | molecular_function | tumor necrosis factor receptor binding |
X | 0006955 | biological_process | immune response |
X | 0016020 | cellular_component | membrane |
Y | 0005164 | molecular_function | tumor necrosis factor receptor binding |
Y | 0006955 | biological_process | immune response |
Y | 0016020 | cellular_component | membrane |
Z | 0005164 | molecular_function | tumor necrosis factor receptor binding |
Z | 0006955 | biological_process | immune response |
Z | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | binding site for residue JNI A 201 |
Chain | Residue |
A | LEU57 |
B | LEU57 |
B | TYR119 |
B | GLY121 |
B | GLY122 |
C | JNI201 |
A | SER60 |
A | TYR119 |
A | LEU120 |
A | GLY121 |
A | GLY122 |
A | TYR151 |
A | ILE155 |
A | JNI202 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue JNI A 202 |
Chain | Residue |
A | HIS15 |
A | JNI201 |
C | JNI201 |
C | JNI202 |
D | JNI201 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue JNI C 201 |
Chain | Residue |
A | JNI201 |
A | JNI202 |
B | LEU55 |
B | LEU157 |
C | TYR119 |
D | SER60 |
D | GLY121 |
D | JNI201 |
site_id | AC4 |
Number of Residues | 8 |
Details | binding site for residue JNI C 202 |
Chain | Residue |
A | SER9 |
A | LEU36 |
A | JNI202 |
C | HIS15 |
C | ASN34 |
C | LEU36 |
C | TYR59 |
C | SER147 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue JNI D 201 |
Chain | Residue |
A | JNI202 |
C | JNI201 |
D | LEU57 |
D | ALA156 |
site_id | AC6 |
Number of Residues | 13 |
Details | binding site for residue JNI F 201 |
Chain | Residue |
F | LEU57 |
F | SER60 |
F | GLN61 |
F | TYR119 |
F | LEU120 |
F | GLY121 |
F | GLY122 |
F | TYR151 |
F | JNI202 |
G | TYR119 |
G | GLY121 |
H | JNI202 |
I | LEU157 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue JNI F 202 |
Chain | Residue |
F | HIS15 |
F | JNI201 |
H | JNI201 |
H | JNI202 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue JNI H 201 |
Chain | Residue |
F | JNI202 |
H | TYR151 |
H | ILE155 |
H | JNI202 |
I | TYR59 |
site_id | AC9 |
Number of Residues | 8 |
Details | binding site for residue JNI H 202 |
Chain | Residue |
F | JNI201 |
F | JNI202 |
G | LEU55 |
G | LEU157 |
H | TYR119 |
H | JNI201 |
I | TYR119 |
I | GLY121 |
site_id | AD1 |
Number of Residues | 15 |
Details | binding site for residue JNI J 201 |
Chain | Residue |
J | LEU57 |
J | ILE58 |
J | TYR59 |
J | SER60 |
J | GLN61 |
J | TYR119 |
J | LEU120 |
J | GLY121 |
J | GLY122 |
J | TYR151 |
J | JNI202 |
K | LEU57 |
K | TYR119 |
K | GLY121 |
L | JNI201 |
site_id | AD2 |
Number of Residues | 3 |
Details | binding site for residue JNI J 202 |
Chain | Residue |
J | HIS15 |
J | JNI201 |
L | JNI201 |
site_id | AD3 |
Number of Residues | 10 |
Details | binding site for residue JNI L 201 |
Chain | Residue |
J | JNI201 |
J | JNI202 |
L | TYR119 |
L | LEU120 |
L | GLY121 |
M | TYR59 |
M | TYR119 |
M | LEU120 |
M | GLY121 |
M | JNI201 |
site_id | AD4 |
Number of Residues | 6 |
Details | binding site for residue JNI M 201 |
Chain | Residue |
L | JNI201 |
M | LYS11 |
M | LEU57 |
M | LEU157 |
L | GLY121 |
L | TYR151 |
site_id | AD5 |
Number of Residues | 14 |
Details | binding site for residue JNI N 201 |
Chain | Residue |
N | LEU57 |
N | TYR59 |
N | SER60 |
N | GLN61 |
N | TYR119 |
N | LEU120 |
N | GLY121 |
N | GLY122 |
N | TYR151 |
O | LEU57 |
O | TYR119 |
O | GLY121 |
O | GLY122 |
P | JNI201 |
site_id | AD6 |
Number of Residues | 4 |
Details | binding site for residue JNI P 201 |
Chain | Residue |
N | JNI201 |
P | ILE155 |
P | JNI202 |
Q | JNI201 |
site_id | AD7 |
Number of Residues | 7 |
Details | binding site for residue JNI P 202 |
Chain | Residue |
O | LEU157 |
P | TYR119 |
P | JNI201 |
Q | TYR119 |
Q | LEU120 |
Q | GLY121 |
Q | JNI201 |
site_id | AD8 |
Number of Residues | 7 |
Details | binding site for residue JNI Q 201 |
Chain | Residue |
P | LEU57 |
P | LEU157 |
P | JNI201 |
P | JNI202 |
Q | LYS11 |
Q | LEU57 |
Q | ALA156 |
site_id | AD9 |
Number of Residues | 8 |
Details | binding site for residue JNI R 201 |
Chain | Residue |
R | LEU57 |
R | SER60 |
R | GLN61 |
R | TYR119 |
R | GLY121 |
R | TYR151 |
S | TYR119 |
S | GLY121 |
site_id | AE1 |
Number of Residues | 6 |
Details | binding site for residue JNI U 201 |
Chain | Residue |
T | GLY121 |
T | TYR151 |
U | LYS11 |
U | LEU57 |
U | TYR59 |
U | ALA156 |
site_id | AE2 |
Number of Residues | 10 |
Details | binding site for residue JNI V 201 |
Chain | Residue |
V | LEU57 |
V | SER60 |
V | GLN61 |
V | TYR119 |
V | LEU120 |
V | TYR151 |
V | JNI202 |
W | TYR119 |
W | GLY121 |
X | JNI202 |
site_id | AE3 |
Number of Residues | 4 |
Details | binding site for residue JNI V 202 |
Chain | Residue |
V | HIS15 |
V | JNI201 |
X | JNI201 |
X | JNI202 |
site_id | AE4 |
Number of Residues | 9 |
Details | binding site for residue JNI X 201 |
Chain | Residue |
V | JNI202 |
X | LEU57 |
X | GLY121 |
X | TYR151 |
X | JNI202 |
Y | LYS11 |
Y | LEU57 |
Y | TYR59 |
Y | LEU157 |
site_id | AE5 |
Number of Residues | 8 |
Details | binding site for residue JNI X 202 |
Chain | Residue |
V | JNI201 |
V | JNI202 |
W | LEU55 |
W | LEU157 |
X | TYR119 |
X | JNI201 |
Y | TYR119 |
Y | GLY121 |
site_id | AE6 |
Number of Residues | 13 |
Details | binding site for residue JNI Z 201 |
Chain | Residue |
Z | LEU57 |
Z | SER60 |
Z | GLN61 |
Z | TYR119 |
Z | LEU120 |
Z | GLY121 |
Z | TYR151 |
Z | JNI202 |
a | LEU57 |
a | TYR119 |
a | GLY121 |
a | GLY122 |
b | JNI202 |
site_id | AE7 |
Number of Residues | 2 |
Details | binding site for residue JNI Z 202 |
Chain | Residue |
Z | JNI201 |
b | JNI201 |
site_id | AE8 |
Number of Residues | 10 |
Details | binding site for residue JNI b 201 |
Chain | Residue |
Z | JNI202 |
b | LEU57 |
b | GLY121 |
b | TYR151 |
b | JNI202 |
c | LYS11 |
c | LEU57 |
c | TYR59 |
c | ALA156 |
c | LEU157 |
site_id | AE9 |
Number of Residues | 6 |
Details | binding site for residue JNI b 202 |
Chain | Residue |
Z | JNI201 |
a | LEU55 |
a | LEU157 |
b | TYR119 |
b | JNI201 |
c | TYR119 |
site_id | AF1 |
Number of Residues | 10 |
Details | binding site for residue JNI d 201 |
Chain | Residue |
d | LEU57 |
d | TYR59 |
d | SER60 |
d | GLN61 |
d | TYR119 |
d | LEU120 |
d | TYR151 |
e | TYR119 |
e | GLY121 |
f | JNI201 |
site_id | AF2 |
Number of Residues | 4 |
Details | binding site for residue JNI f 201 |
Chain | Residue |
d | HIS15 |
d | JNI201 |
f | ILE155 |
f | JNI202 |
site_id | AF3 |
Number of Residues | 11 |
Details | binding site for residue JNI f 202 |
Chain | Residue |
d | SER9 |
d | ASP10 |
d | VAL13 |
d | ASN39 |
d | ILE155 |
f | PRO8 |
f | SER9 |
f | HIS15 |
f | ALA33 |
f | ASN34 |
f | JNI201 |
site_id | AF4 |
Number of Residues | 10 |
Details | binding site for residue JNI h 201 |
Chain | Residue |
h | LEU57 |
h | SER60 |
h | TYR119 |
h | LEU120 |
h | TYR151 |
i | LEU57 |
i | TYR119 |
i | GLY121 |
j | JNI202 |
k | LYS11 |
site_id | AF5 |
Number of Residues | 1 |
Details | binding site for residue JNI h 202 |
Chain | Residue |
j | JNI201 |
site_id | AF6 |
Number of Residues | 6 |
Details | binding site for residue JNI j 201 |
Chain | Residue |
h | JNI202 |
j | GLY121 |
j | TYR151 |
j | JNI202 |
k | LEU57 |
k | LEU157 |
site_id | AF7 |
Number of Residues | 6 |
Details | binding site for residue JNI j 202 |
Chain | Residue |
h | JNI201 |
i | LEU55 |
i | LEU157 |
j | TYR119 |
j | JNI201 |
k | TYR119 |
site_id | AF8 |
Number of Residues | 11 |
Details | binding site for residue JNI l 201 |
Chain | Residue |
l | LEU57 |
l | SER60 |
l | GLN61 |
l | PRO117 |
l | TYR119 |
l | LEU120 |
l | TYR151 |
m | TYR119 |
m | GLY121 |
n | JNI201 |
n | JNI202 |
site_id | AF9 |
Number of Residues | 2 |
Details | binding site for residue JNI n 201 |
Chain | Residue |
l | JNI201 |
o | JNI201 |
site_id | AG1 |
Number of Residues | 6 |
Details | binding site for residue JNI n 202 |
Chain | Residue |
l | JNI201 |
m | LEU55 |
m | LEU157 |
n | TYR119 |
o | TYR119 |
o | JNI201 |
site_id | AG2 |
Number of Residues | 8 |
Details | binding site for residue JNI o 201 |
Chain | Residue |
n | TYR59 |
n | GLY121 |
n | JNI201 |
n | JNI202 |
o | LYS11 |
o | LEU57 |
o | ALA156 |
o | LEU157 |
site_id | AG3 |
Number of Residues | 10 |
Details | binding site for residue JNI p 201 |
Chain | Residue |
p | LEU57 |
p | TYR59 |
p | GLN61 |
p | TYR119 |
p | LEU120 |
p | TYR151 |
p | JNI202 |
q | TYR119 |
q | GLY121 |
r | JNI202 |
site_id | AG4 |
Number of Residues | 8 |
Details | binding site for residue JNI p 202 |
Chain | Residue |
p | HIS15 |
p | JNI201 |
r | SER9 |
r | VAL13 |
r | HIS15 |
r | ILE155 |
r | JNI201 |
r | JNI202 |
site_id | AG5 |
Number of Residues | 7 |
Details | binding site for residue JNI r 201 |
Chain | Residue |
p | JNI202 |
r | SER60 |
r | GLY121 |
r | TYR151 |
r | ILE155 |
r | JNI202 |
s | TYR59 |
site_id | AG6 |
Number of Residues | 7 |
Details | binding site for residue JNI r 202 |
Chain | Residue |
p | JNI201 |
p | JNI202 |
q | LEU55 |
q | LEU157 |
r | TYR119 |
r | JNI201 |
s | TYR119 |
site_id | AG7 |
Number of Residues | 12 |
Details | binding site for residue JNI t 201 |
Chain | Residue |
t | LEU57 |
t | SER60 |
t | TYR119 |
t | LEU120 |
t | GLY121 |
t | GLY122 |
t | TYR151 |
t | JNI202 |
u | LEU57 |
u | TYR119 |
u | GLY121 |
w | LEU157 |
site_id | AG8 |
Number of Residues | 5 |
Details | binding site for residue JNI t 202 |
Chain | Residue |
t | HIS15 |
t | JNI201 |
v | SER9 |
v | JNI201 |
v | JNI202 |
site_id | AG9 |
Number of Residues | 7 |
Details | binding site for residue JNI v 201 |
Chain | Residue |
t | JNI202 |
v | TYR119 |
v | GLY121 |
v | TYR151 |
v | JNI202 |
w | LEU57 |
w | TYR59 |
site_id | AH1 |
Number of Residues | 6 |
Details | binding site for residue JNI v 202 |
Chain | Residue |
t | JNI202 |
u | LEU55 |
u | LEU157 |
v | TYR119 |
v | JNI201 |
w | TYR119 |
site_id | AH2 |
Number of Residues | 21 |
Details | binding site for Di-peptide GLU s 23 and ARG D 32 |
Chain | Residue |
C | VAL91 |
D | GLN21 |
D | ALA22 |
D | GLY24 |
D | GLN25 |
D | ASN30 |
D | ARG31 |
D | ALA33 |
D | ASN34 |
D | ALA35 |
D | SER147 |
D | SER147 |
s | PRO20 |
s | ALA22 |
s | GLY24 |
s | GLN25 |
s | ASN30 |
s | ARG31 |
s | ALA33 |
s | ASN34 |
s | ALA35 |
Functional Information from PROSITE/UniProt
site_id | PS00251 |
Number of Residues | 17 |
Details | THD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LvVPsEGLYLIysQVlF |
Chain | Residue | Details |
A | LEU48-PHE64 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 48 |
Details | CARBOHYD: O-linked (GalNAc...) serine; in soluble form => ECO:0000269|PubMed:8631363 |
Chain | Residue | Details |
A | SER4 | |
K | SER4 | |
L | SER4 | |
M | SER4 | |
N | SER4 | |
O | SER4 | |
P | SER4 | |
Q | SER4 | |
R | SER4 | |
S | SER4 | |
T | SER4 | |
B | SER4 | |
U | SER4 | |
V | SER4 | |
W | SER4 | |
X | SER4 | |
Y | SER4 | |
Z | SER4 | |
a | SER4 | |
b | SER4 | |
c | SER4 | |
d | SER4 | |
C | SER4 | |
e | SER4 | |
f | SER4 | |
g | SER4 | |
h | SER4 | |
i | SER4 | |
j | SER4 | |
k | SER4 | |
l | SER4 | |
m | SER4 | |
n | SER4 | |
D | SER4 | |
o | SER4 | |
p | SER4 | |
q | SER4 | |
r | SER4 | |
s | SER4 | |
t | SER4 | |
u | SER4 | |
v | SER4 | |
w | SER4 | |
F | SER4 | |
G | SER4 | |
H | SER4 | |
I | SER4 | |
J | SER4 |