Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5MU8

HUMAN TNF-ALPHA IN COMPLEX WITH JNJ525

Functional Information from GO Data
ChainGOidnamespacecontents
a0005164molecular_functiontumor necrosis factor receptor binding
a0006955biological_processimmune response
a0016020cellular_componentmembrane
A0005164molecular_functiontumor necrosis factor receptor binding
A0006955biological_processimmune response
A0016020cellular_componentmembrane
b0005164molecular_functiontumor necrosis factor receptor binding
b0006955biological_processimmune response
b0016020cellular_componentmembrane
B0005164molecular_functiontumor necrosis factor receptor binding
B0006955biological_processimmune response
B0016020cellular_componentmembrane
c0005164molecular_functiontumor necrosis factor receptor binding
c0006955biological_processimmune response
c0016020cellular_componentmembrane
C0005164molecular_functiontumor necrosis factor receptor binding
C0006955biological_processimmune response
C0016020cellular_componentmembrane
d0005164molecular_functiontumor necrosis factor receptor binding
d0006955biological_processimmune response
d0016020cellular_componentmembrane
D0005164molecular_functiontumor necrosis factor receptor binding
D0006955biological_processimmune response
D0016020cellular_componentmembrane
e0005164molecular_functiontumor necrosis factor receptor binding
e0006955biological_processimmune response
e0016020cellular_componentmembrane
f0005164molecular_functiontumor necrosis factor receptor binding
f0006955biological_processimmune response
f0016020cellular_componentmembrane
F0005164molecular_functiontumor necrosis factor receptor binding
F0006955biological_processimmune response
F0016020cellular_componentmembrane
g0005164molecular_functiontumor necrosis factor receptor binding
g0006955biological_processimmune response
g0016020cellular_componentmembrane
G0005164molecular_functiontumor necrosis factor receptor binding
G0006955biological_processimmune response
G0016020cellular_componentmembrane
h0005164molecular_functiontumor necrosis factor receptor binding
h0006955biological_processimmune response
h0016020cellular_componentmembrane
H0005164molecular_functiontumor necrosis factor receptor binding
H0006955biological_processimmune response
H0016020cellular_componentmembrane
i0005164molecular_functiontumor necrosis factor receptor binding
i0006955biological_processimmune response
i0016020cellular_componentmembrane
I0005164molecular_functiontumor necrosis factor receptor binding
I0006955biological_processimmune response
I0016020cellular_componentmembrane
j0005164molecular_functiontumor necrosis factor receptor binding
j0006955biological_processimmune response
j0016020cellular_componentmembrane
J0005164molecular_functiontumor necrosis factor receptor binding
J0006955biological_processimmune response
J0016020cellular_componentmembrane
k0005164molecular_functiontumor necrosis factor receptor binding
k0006955biological_processimmune response
k0016020cellular_componentmembrane
K0005164molecular_functiontumor necrosis factor receptor binding
K0006955biological_processimmune response
K0016020cellular_componentmembrane
l0005164molecular_functiontumor necrosis factor receptor binding
l0006955biological_processimmune response
l0016020cellular_componentmembrane
L0005164molecular_functiontumor necrosis factor receptor binding
L0006955biological_processimmune response
L0016020cellular_componentmembrane
m0005164molecular_functiontumor necrosis factor receptor binding
m0006955biological_processimmune response
m0016020cellular_componentmembrane
M0005164molecular_functiontumor necrosis factor receptor binding
M0006955biological_processimmune response
M0016020cellular_componentmembrane
n0005164molecular_functiontumor necrosis factor receptor binding
n0006955biological_processimmune response
n0016020cellular_componentmembrane
N0005164molecular_functiontumor necrosis factor receptor binding
N0006955biological_processimmune response
N0016020cellular_componentmembrane
o0005164molecular_functiontumor necrosis factor receptor binding
o0006955biological_processimmune response
o0016020cellular_componentmembrane
O0005164molecular_functiontumor necrosis factor receptor binding
O0006955biological_processimmune response
O0016020cellular_componentmembrane
p0005164molecular_functiontumor necrosis factor receptor binding
p0006955biological_processimmune response
p0016020cellular_componentmembrane
P0005164molecular_functiontumor necrosis factor receptor binding
P0006955biological_processimmune response
P0016020cellular_componentmembrane
q0005164molecular_functiontumor necrosis factor receptor binding
q0006955biological_processimmune response
q0016020cellular_componentmembrane
Q0005164molecular_functiontumor necrosis factor receptor binding
Q0006955biological_processimmune response
Q0016020cellular_componentmembrane
r0005164molecular_functiontumor necrosis factor receptor binding
r0006955biological_processimmune response
r0016020cellular_componentmembrane
R0005164molecular_functiontumor necrosis factor receptor binding
R0006955biological_processimmune response
R0016020cellular_componentmembrane
s0005164molecular_functiontumor necrosis factor receptor binding
s0006955biological_processimmune response
s0016020cellular_componentmembrane
S0005164molecular_functiontumor necrosis factor receptor binding
S0006955biological_processimmune response
S0016020cellular_componentmembrane
t0005164molecular_functiontumor necrosis factor receptor binding
t0006955biological_processimmune response
t0016020cellular_componentmembrane
T0005164molecular_functiontumor necrosis factor receptor binding
T0006955biological_processimmune response
T0016020cellular_componentmembrane
u0005164molecular_functiontumor necrosis factor receptor binding
u0006955biological_processimmune response
u0016020cellular_componentmembrane
U0005164molecular_functiontumor necrosis factor receptor binding
U0006955biological_processimmune response
U0016020cellular_componentmembrane
v0005164molecular_functiontumor necrosis factor receptor binding
v0006955biological_processimmune response
v0016020cellular_componentmembrane
V0005164molecular_functiontumor necrosis factor receptor binding
V0006955biological_processimmune response
V0016020cellular_componentmembrane
w0005164molecular_functiontumor necrosis factor receptor binding
w0006955biological_processimmune response
w0016020cellular_componentmembrane
W0005164molecular_functiontumor necrosis factor receptor binding
W0006955biological_processimmune response
W0016020cellular_componentmembrane
X0005164molecular_functiontumor necrosis factor receptor binding
X0006955biological_processimmune response
X0016020cellular_componentmembrane
Y0005164molecular_functiontumor necrosis factor receptor binding
Y0006955biological_processimmune response
Y0016020cellular_componentmembrane
Z0005164molecular_functiontumor necrosis factor receptor binding
Z0006955biological_processimmune response
Z0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue JNI A 201
ChainResidue
ALEU57
BLEU57
BTYR119
BGLY121
BGLY122
CJNI201
ASER60
ATYR119
ALEU120
AGLY121
AGLY122
ATYR151
AILE155
AJNI202

site_idAC2
Number of Residues5
Detailsbinding site for residue JNI A 202
ChainResidue
AHIS15
AJNI201
CJNI201
CJNI202
DJNI201

site_idAC3
Number of Residues8
Detailsbinding site for residue JNI C 201
ChainResidue
AJNI201
AJNI202
BLEU55
BLEU157
CTYR119
DSER60
DGLY121
DJNI201

site_idAC4
Number of Residues8
Detailsbinding site for residue JNI C 202
ChainResidue
ASER9
ALEU36
AJNI202
CHIS15
CASN34
CLEU36
CTYR59
CSER147

site_idAC5
Number of Residues4
Detailsbinding site for residue JNI D 201
ChainResidue
AJNI202
CJNI201
DLEU57
DALA156

site_idAC6
Number of Residues13
Detailsbinding site for residue JNI F 201
ChainResidue
FLEU57
FSER60
FGLN61
FTYR119
FLEU120
FGLY121
FGLY122
FTYR151
FJNI202
GTYR119
GGLY121
HJNI202
ILEU157

site_idAC7
Number of Residues4
Detailsbinding site for residue JNI F 202
ChainResidue
FHIS15
FJNI201
HJNI201
HJNI202

site_idAC8
Number of Residues5
Detailsbinding site for residue JNI H 201
ChainResidue
FJNI202
HTYR151
HILE155
HJNI202
ITYR59

site_idAC9
Number of Residues8
Detailsbinding site for residue JNI H 202
ChainResidue
FJNI201
FJNI202
GLEU55
GLEU157
HTYR119
HJNI201
ITYR119
IGLY121

site_idAD1
Number of Residues15
Detailsbinding site for residue JNI J 201
ChainResidue
JLEU57
JILE58
JTYR59
JSER60
JGLN61
JTYR119
JLEU120
JGLY121
JGLY122
JTYR151
JJNI202
KLEU57
KTYR119
KGLY121
LJNI201

site_idAD2
Number of Residues3
Detailsbinding site for residue JNI J 202
ChainResidue
JHIS15
JJNI201
LJNI201

site_idAD3
Number of Residues10
Detailsbinding site for residue JNI L 201
ChainResidue
JJNI201
JJNI202
LTYR119
LLEU120
LGLY121
MTYR59
MTYR119
MLEU120
MGLY121
MJNI201

site_idAD4
Number of Residues6
Detailsbinding site for residue JNI M 201
ChainResidue
LJNI201
MLYS11
MLEU57
MLEU157
LGLY121
LTYR151

site_idAD5
Number of Residues14
Detailsbinding site for residue JNI N 201
ChainResidue
NLEU57
NTYR59
NSER60
NGLN61
NTYR119
NLEU120
NGLY121
NGLY122
NTYR151
OLEU57
OTYR119
OGLY121
OGLY122
PJNI201

site_idAD6
Number of Residues4
Detailsbinding site for residue JNI P 201
ChainResidue
NJNI201
PILE155
PJNI202
QJNI201

site_idAD7
Number of Residues7
Detailsbinding site for residue JNI P 202
ChainResidue
OLEU157
PTYR119
PJNI201
QTYR119
QLEU120
QGLY121
QJNI201

site_idAD8
Number of Residues7
Detailsbinding site for residue JNI Q 201
ChainResidue
PLEU57
PLEU157
PJNI201
PJNI202
QLYS11
QLEU57
QALA156

site_idAD9
Number of Residues8
Detailsbinding site for residue JNI R 201
ChainResidue
RLEU57
RSER60
RGLN61
RTYR119
RGLY121
RTYR151
STYR119
SGLY121

site_idAE1
Number of Residues6
Detailsbinding site for residue JNI U 201
ChainResidue
TGLY121
TTYR151
ULYS11
ULEU57
UTYR59
UALA156

site_idAE2
Number of Residues10
Detailsbinding site for residue JNI V 201
ChainResidue
VLEU57
VSER60
VGLN61
VTYR119
VLEU120
VTYR151
VJNI202
WTYR119
WGLY121
XJNI202

site_idAE3
Number of Residues4
Detailsbinding site for residue JNI V 202
ChainResidue
VHIS15
VJNI201
XJNI201
XJNI202

site_idAE4
Number of Residues9
Detailsbinding site for residue JNI X 201
ChainResidue
VJNI202
XLEU57
XGLY121
XTYR151
XJNI202
YLYS11
YLEU57
YTYR59
YLEU157

site_idAE5
Number of Residues8
Detailsbinding site for residue JNI X 202
ChainResidue
VJNI201
VJNI202
WLEU55
WLEU157
XTYR119
XJNI201
YTYR119
YGLY121

site_idAE6
Number of Residues13
Detailsbinding site for residue JNI Z 201
ChainResidue
ZLEU57
ZSER60
ZGLN61
ZTYR119
ZLEU120
ZGLY121
ZTYR151
ZJNI202
aLEU57
aTYR119
aGLY121
aGLY122
bJNI202

site_idAE7
Number of Residues2
Detailsbinding site for residue JNI Z 202
ChainResidue
ZJNI201
bJNI201

site_idAE8
Number of Residues10
Detailsbinding site for residue JNI b 201
ChainResidue
ZJNI202
bLEU57
bGLY121
bTYR151
bJNI202
cLYS11
cLEU57
cTYR59
cALA156
cLEU157

site_idAE9
Number of Residues6
Detailsbinding site for residue JNI b 202
ChainResidue
ZJNI201
aLEU55
aLEU157
bTYR119
bJNI201
cTYR119

site_idAF1
Number of Residues10
Detailsbinding site for residue JNI d 201
ChainResidue
dLEU57
dTYR59
dSER60
dGLN61
dTYR119
dLEU120
dTYR151
eTYR119
eGLY121
fJNI201

site_idAF2
Number of Residues4
Detailsbinding site for residue JNI f 201
ChainResidue
dHIS15
dJNI201
fILE155
fJNI202

site_idAF3
Number of Residues11
Detailsbinding site for residue JNI f 202
ChainResidue
dSER9
dASP10
dVAL13
dASN39
dILE155
fPRO8
fSER9
fHIS15
fALA33
fASN34
fJNI201

site_idAF4
Number of Residues10
Detailsbinding site for residue JNI h 201
ChainResidue
hLEU57
hSER60
hTYR119
hLEU120
hTYR151
iLEU57
iTYR119
iGLY121
jJNI202
kLYS11

site_idAF5
Number of Residues1
Detailsbinding site for residue JNI h 202
ChainResidue
jJNI201

site_idAF6
Number of Residues6
Detailsbinding site for residue JNI j 201
ChainResidue
hJNI202
jGLY121
jTYR151
jJNI202
kLEU57
kLEU157

site_idAF7
Number of Residues6
Detailsbinding site for residue JNI j 202
ChainResidue
hJNI201
iLEU55
iLEU157
jTYR119
jJNI201
kTYR119

site_idAF8
Number of Residues11
Detailsbinding site for residue JNI l 201
ChainResidue
lLEU57
lSER60
lGLN61
lPRO117
lTYR119
lLEU120
lTYR151
mTYR119
mGLY121
nJNI201
nJNI202

site_idAF9
Number of Residues2
Detailsbinding site for residue JNI n 201
ChainResidue
lJNI201
oJNI201

site_idAG1
Number of Residues6
Detailsbinding site for residue JNI n 202
ChainResidue
lJNI201
mLEU55
mLEU157
nTYR119
oTYR119
oJNI201

site_idAG2
Number of Residues8
Detailsbinding site for residue JNI o 201
ChainResidue
nTYR59
nGLY121
nJNI201
nJNI202
oLYS11
oLEU57
oALA156
oLEU157

site_idAG3
Number of Residues10
Detailsbinding site for residue JNI p 201
ChainResidue
pLEU57
pTYR59
pGLN61
pTYR119
pLEU120
pTYR151
pJNI202
qTYR119
qGLY121
rJNI202

site_idAG4
Number of Residues8
Detailsbinding site for residue JNI p 202
ChainResidue
pHIS15
pJNI201
rSER9
rVAL13
rHIS15
rILE155
rJNI201
rJNI202

site_idAG5
Number of Residues7
Detailsbinding site for residue JNI r 201
ChainResidue
pJNI202
rSER60
rGLY121
rTYR151
rILE155
rJNI202
sTYR59

site_idAG6
Number of Residues7
Detailsbinding site for residue JNI r 202
ChainResidue
pJNI201
pJNI202
qLEU55
qLEU157
rTYR119
rJNI201
sTYR119

site_idAG7
Number of Residues12
Detailsbinding site for residue JNI t 201
ChainResidue
tLEU57
tSER60
tTYR119
tLEU120
tGLY121
tGLY122
tTYR151
tJNI202
uLEU57
uTYR119
uGLY121
wLEU157

site_idAG8
Number of Residues5
Detailsbinding site for residue JNI t 202
ChainResidue
tHIS15
tJNI201
vSER9
vJNI201
vJNI202

site_idAG9
Number of Residues7
Detailsbinding site for residue JNI v 201
ChainResidue
tJNI202
vTYR119
vGLY121
vTYR151
vJNI202
wLEU57
wTYR59

site_idAH1
Number of Residues6
Detailsbinding site for residue JNI v 202
ChainResidue
tJNI202
uLEU55
uLEU157
vTYR119
vJNI201
wTYR119

site_idAH2
Number of Residues21
Detailsbinding site for Di-peptide GLU s 23 and ARG D 32
ChainResidue
CVAL91
DGLN21
DALA22
DGLY24
DGLN25
DASN30
DARG31
DALA33
DASN34
DALA35
DSER147
DSER147
sPRO20
sALA22
sGLY24
sGLN25
sASN30
sARG31
sALA33
sASN34
sALA35

Functional Information from PROSITE/UniProt
site_idPS00251
Number of Residues17
DetailsTHD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LvVPsEGLYLIysQVlF
ChainResidueDetails
ALEU48-PHE64

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues48
DetailsCARBOHYD: O-linked (GalNAc...) serine; in soluble form => ECO:0000269|PubMed:8631363
ChainResidueDetails
ASER4
KSER4
LSER4
MSER4
NSER4
OSER4
PSER4
QSER4
RSER4
SSER4
TSER4
BSER4
USER4
VSER4
WSER4
XSER4
YSER4
ZSER4
aSER4
bSER4
cSER4
dSER4
CSER4
eSER4
fSER4
gSER4
hSER4
iSER4
jSER4
kSER4
lSER4
mSER4
nSER4
DSER4
oSER4
pSER4
qSER4
rSER4
sSER4
tSER4
uSER4
vSER4
wSER4
FSER4
GSER4
HSER4
ISER4
JSER4

222926

PDB entries from 2024-07-24

PDB statisticsPDBj update infoContact PDBjnumon