5MTF
A modular route to novel potent and selective inhibitors of rhomboid intramembrane proteases
Summary for 5MTF
Entry DOI | 10.2210/pdb5mtf/pdb |
Descriptor | Rhomboid protease GlpG, inhibitor, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | rhomboid protease, specificity, inhibition, ketoamide, hydrolase |
Biological source | Escherichia coli O45:K1 (strain S88 / ExPEC) More |
Cellular location | Cell inner membrane ; Multi-pass membrane protein : B7MDQ0 |
Total number of polymer chains | 2 |
Total formula weight | 23930.46 |
Authors | Ticha, A.,Stanchev, S.,Vinothkumar, K.R.,Mikles, D.C.,Pachl, P.,Svehlova, K.,Nguyen, M.T.N.,Verhelst, S.H.L.,Johnson, D.,Bachovchin, D.,Lepsik, M.,Majer, P.,Strisovsky, K. (deposition date: 2017-01-09, release date: 2017-11-15, Last modification date: 2024-01-17) |
Primary citation | Ticha, A.,Stanchev, S.,Vinothkumar, K.R.,Mikles, D.C.,Pachl, P.,Began, J.,Skerle, J.,Svehlova, K.,Nguyen, M.T.N.,Verhelst, S.H.L.,Johnson, D.C.,Bachovchin, D.A.,Lepsik, M.,Majer, P.,Strisovsky, K. General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24:1523-1536.e4, 2017 Cited by PubMed: 29107700DOI: 10.1016/j.chembiol.2017.09.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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