5MJ4

INTERLEUKIN-23 COMPLEX WITH AN ANTAGONISTIC ALPHABODY, CRYSTAL FORM 2

Replaces:  4OG9
Summary for 5MJ4
Related5MJ3
DescriptorInterleukin-12 subunit beta, Interleukin-23 subunit alpha, ALPHABODY MA12, ... (4 entities in total)
Functional Keywordssingle-chain antiparallel triple-helix coiled-coil, immunoglobulin-like, 4-alpha helical bundle, antagonist, n-linked glycosylation, cytokine-antagonist complex, immune system
Biological sourceHomo sapiens (Human)
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Total number of polymer chains3
Total formula weight67351.65
Authors
Desmet, J.,Verstraete, K.,Bloch, Y.,Lorent, E.,Wen, Y.,Devreese, B.,Vandenbroucke, K.,Loverix, S.,Hettmann, T.,Deroo, S.,Somers, K.,Henderikx, P.,Lasters, I.,Savvides, S. (deposition date: 2016-11-29, release date: 2017-01-11, Last modification date: 2020-07-29)
Primary citationBloch, Y.,Deroo, S.,Desmet, J.,Devreese, B.,Henderikx, P.,Hettmann, T.,Lasters, I.,Lorent, E.,Loverix, S.,Savvides, S.,Somers, K.,Vandenbroucke, K.,Verstraete, K.,Wen, Y.
STRUCTURAL BASIS OF IL-23 ANTAGONISM BY AN ALPHABODY PROTEIN
Nature Communications, 5:5237-, 2014
PubMed: 25354530
DOI: 110.1038/NCOMMS6237
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.4 Å)
Structure validation
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PDB entries from 2021-06-09