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5MJ4

INTERLEUKIN-23 COMPLEX WITH AN ANTAGONISTIC ALPHABODY, CRYSTAL FORM 2

Replaces:  4OG9
Functional Information from GO Data
ChainGOidnamespacecontents
A0001817biological_processregulation of cytokine production
A0001916biological_processpositive regulation of T cell mediated cytotoxicity
A0002230biological_processpositive regulation of defense response to virus by host
A0002323biological_processnatural killer cell activation involved in immune response
A0002827biological_processpositive regulation of T-helper 1 type immune response
A0002860biological_processpositive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
A0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
A0004896molecular_functioncytokine receptor activity
A0005125molecular_functioncytokine activity
A0005126molecular_functioncytokine receptor binding
A0005143molecular_functioninterleukin-12 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005788cellular_componentendoplasmic reticulum lumen
A0005829cellular_componentcytosol
A0007166biological_processcell surface receptor signaling pathway
A0008083molecular_functiongrowth factor activity
A0008283biological_processcell population proliferation
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010033biological_processresponse to organic substance
A0010224biological_processresponse to UV-B
A0010536biological_processpositive regulation of activation of Janus kinase activity
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0019221biological_processcytokine-mediated signaling pathway
A0019953biological_processsexual reproduction
A0019955molecular_functioncytokine binding
A0030101biological_processnatural killer cell activation
A0031906cellular_componentlate endosome lumen
A0032693biological_processnegative regulation of interleukin-10 production
A0032700biological_processnegative regulation of interleukin-17 production
A0032725biological_processpositive regulation of granulocyte macrophage colony-stimulating factor production
A0032729biological_processpositive regulation of type II interferon production
A0032733biological_processpositive regulation of interleukin-10 production
A0032735biological_processpositive regulation of interleukin-12 production
A0032740biological_processpositive regulation of interleukin-17 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032816biological_processpositive regulation of natural killer cell activation
A0032819biological_processpositive regulation of natural killer cell proliferation
A0032946biological_processpositive regulation of mononuclear cell proliferation
A0034105biological_processpositive regulation of tissue remodeling
A0034393biological_processpositive regulation of smooth muscle cell apoptotic process
A0035722biological_processinterleukin-12-mediated signaling pathway
A0042088biological_processT-helper 1 type immune response
A0042093biological_processT-helper cell differentiation
A0042098biological_processT cell proliferation
A0042102biological_processpositive regulation of T cell proliferation
A0042104biological_processpositive regulation of activated T cell proliferation
A0042164molecular_functioninterleukin-12 alpha subunit binding
A0042509biological_processregulation of tyrosine phosphorylation of STAT protein
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0042802molecular_functionidentical protein binding
A0042832biological_processdefense response to protozoan
A0043235cellular_componentreceptor complex
A0043382biological_processpositive regulation of memory T cell differentiation
A0043514cellular_componentinterleukin-12 complex
A0044877molecular_functionprotein-containing complex binding
A0045519molecular_functioninterleukin-23 receptor binding
A0045672biological_processpositive regulation of osteoclast differentiation
A0045785biological_processpositive regulation of cell adhesion
A0046982molecular_functionprotein heterodimerization activity
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0050671biological_processpositive regulation of lymphocyte proliferation
A0050709biological_processnegative regulation of protein secretion
A0050729biological_processpositive regulation of inflammatory response
A0050829biological_processdefense response to Gram-negative bacterium
A0051135biological_processpositive regulation of NK T cell activation
A0051142biological_processpositive regulation of NK T cell proliferation
A0051607biological_processdefense response to virus
A0070743cellular_componentinterleukin-23 complex
A0071222biological_processcellular response to lipopolysaccharide
A0071346biological_processcellular response to type II interferon
A1900747biological_processnegative regulation of vascular endothelial growth factor signaling pathway
A1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
A1903588biological_processnegative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
A2000318biological_processpositive regulation of T-helper 17 type immune response
A2000330biological_processpositive regulation of T-helper 17 cell lineage commitment
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002230biological_processpositive regulation of defense response to virus by host
B0002376biological_processimmune system process
B0002827biological_processpositive regulation of T-helper 1 type immune response
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005788cellular_componentendoplasmic reticulum lumen
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0007165biological_processsignal transduction
B0010536biological_processpositive regulation of activation of Janus kinase activity
B0032693biological_processnegative regulation of interleukin-10 production
B0032725biological_processpositive regulation of granulocyte macrophage colony-stimulating factor production
B0032729biological_processpositive regulation of type II interferon production
B0032733biological_processpositive regulation of interleukin-10 production
B0032735biological_processpositive regulation of interleukin-12 production
B0032740biological_processpositive regulation of interleukin-17 production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0032816biological_processpositive regulation of natural killer cell activation
B0032819biological_processpositive regulation of natural killer cell proliferation
B0034105biological_processpositive regulation of tissue remodeling
B0042098biological_processT cell proliferation
B0042102biological_processpositive regulation of T cell proliferation
B0042104biological_processpositive regulation of activated T cell proliferation
B0042509biological_processregulation of tyrosine phosphorylation of STAT protein
B0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
B0043382biological_processpositive regulation of memory T cell differentiation
B0045087biological_processinnate immune response
B0045519molecular_functioninterleukin-23 receptor binding
B0045672biological_processpositive regulation of osteoclast differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048771biological_processtissue remodeling
B0050729biological_processpositive regulation of inflammatory response
B0050829biological_processdefense response to Gram-negative bacterium
B0051135biological_processpositive regulation of NK T cell activation
B0051142biological_processpositive regulation of NK T cell proliferation
B0051607biological_processdefense response to virus
B0070743cellular_componentinterleukin-23 complex
B0090023biological_processpositive regulation of neutrophil chemotaxis
B1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
B2000318biological_processpositive regulation of T-helper 17 type immune response
B2000330biological_processpositive regulation of T-helper 17 cell lineage commitment
Functional Information from PROSITE/UniProt
site_idPS01354
Number of Residues43
DetailsHEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. IkPDPPknLqlkplknsrq.VevsWeyPdTWstphsyFsLtFcV
ChainResidueDetails
AILE233-VAL275

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN135

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10899108
ChainResidueDetails
AASN222

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: C-linked (Man) tryptophan => ECO:0000269|PubMed:10207176
ChainResidueDetails
ATRP319

217705

PDB entries from 2024-03-27

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