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5MJ4

INTERLEUKIN-23 COMPLEX WITH AN ANTAGONISTIC ALPHABODY, CRYSTAL FORM 2

Replaces:  4OG9
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Interleukin-12 subunit betapolymer30634739.91UniProt (P29460)
Pfam (PF10420)
Homo sapiens (Human)IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit,CLMF p40,IL-12 subunit p40,NK cell stimulatory factor chain 2,NKSF2
2B
(B)
Interleukin-23 subunit alphapolymer17919812.31UniProt (Q9NPF7)
Pfam (PF16649)
Homo sapiens (Human)IL-23-A,Interleukin-23 subunit p19,IL-23p19
3C
(C)
ALPHABODY MA12polymer11811888.51synthetic construct
4D
(D)
alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched910.81In PDB
GlyTouCan (G22768VO)
Sequence modifications
B: 20 - 189 (UniProt: Q9NPF7)
PDBExternal DatabaseDetails
Gly 190-expression tag
Thr 191-expression tag
Lys 192-expression tag
His 193-expression tag
His 194-expression tag
His 195-expression tag
His 196-expression tag
His 197-expression tag
His 198-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight66440.8
BranchedNumber of molecules1
Total formula weight910.8
All*Total formula weight67351.6
*Water molecules are not included.

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PDB entries from 2024-11-20

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