5LSP

107_A07 Fab in complex with fragment of the Met receptor

Summary for 5LSP

• Entry DOI: 10.2210/pdb5lsp/pdb
• Descriptor: Hepatocyte growth factor receptor, 107_A07 Fab heavy chain, 107_A07 Fab light chain, ... (6 entities in total)
• Functional Keywords: fab, beta propeller, ig-like domain, cell signalling, met receptor, antibody binding, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 149676.07

Authors

DiCara, D.,Chirgadze, D.Y.,Pope, A.,Karatt-Vellatt, A.,Winter, A.,van den Heuvel, J.,Gherardi, E.,McCafferty, J. (deposition date: 2016-09-05, release date: 2017-09-13, Last modification date: 2020-07-29)

• Primary citation: DiCara, D.M.,Chirgadze, D.Y.,Pope, A.R.,Karatt-Vellatt, A.,Winter, A.,Slavny, P.,van den Heuvel, J.,Parthiban, K.,Holland, J.,Packman, L.C.,Mavria, G.,Hoffmann, J.,Birchmeier, W.,Gherardi, E.,McCafferty, J.; Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain.; Sci Rep, 7:9000-9000, 2017; PubMed: 28827556; DOI: 10.1038/s41598-017-09460-2

Experimental method

X-RAY DIFFRACTION (2.605 Å)