5LMB
HUMAN SPLEEN TYROSINE KINASE KINASE DOMAIN IN COMPLEX WITH AZANAPHTHYRIDINE INHIBITOR
Summary for 5LMB
Entry DOI | 10.2210/pdb5lmb/pdb |
Related | 5LMA |
Descriptor | Tyrosine-protein kinase SYK, 7-[6-(dimethylamino)pyridin-3-yl]-~{N}-[[(3~{S})-piperidin-3-yl]methyl]pyrido[3,4-b]pyrazin-5-amine, GLYCEROL, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 65695.56 |
Authors | Somers, D.O.,Neu, M. (deposition date: 2016-07-29, release date: 2016-09-14, Last modification date: 2024-05-01) |
Primary citation | Garton, N.S.,Barker, M.D.,Davis, R.P.,Douault, C.,Hooper-Greenhill, E.,Jones, E.,Lewis, H.D.,Liddle, J.,Lugo, D.,McCleary, S.,Preston, A.G.,Ramirez-Molina, C.,Neu, M.,Shipley, T.J.,Somers, D.O.,Watson, R.J.,Wilson, D.M. Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors. Bioorg.Med.Chem.Lett., 26:4606-4612, 2016 Cited by PubMed: 27578246DOI: 10.1016/j.bmcl.2016.08.070 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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