5LLS
Porcine dipeptidyl peptidase IV in complex with 8-(3-aminopiperidin-1-yl)-7-[(2-bromophenyl)methyl]-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Summary for 5LLS
Entry DOI | 10.2210/pdb5lls/pdb |
Descriptor | Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | peptidase, inhibitor, complex, hydrolase |
Biological source | Sus scrofa (Pig) |
Total number of polymer chains | 4 |
Total formula weight | 364428.55 |
Authors | Nar, H.,Blaesse, M. (deposition date: 2016-07-28, release date: 2016-09-14, Last modification date: 2024-01-10) |
Primary citation | Schnapp, G.,Klein, T.,Hoevels, Y.,Bakker, R.A.,Nar, H. Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to Structure. J.Med.Chem., 59:7466-7477, 2016 Cited by PubMed: 27438064DOI: 10.1021/acs.jmedchem.6b00475 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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