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5LLS

Porcine dipeptidyl peptidase IV in complex with 8-(3-aminopiperidin-1-yl)-7-[(2-bromophenyl)methyl]-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione

Functional Information from GO Data
ChainGOidnamespacecontents
A0002020molecular_functionprotease binding
A0004177molecular_functionaminopeptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005102molecular_functionsignaling receptor binding
A0005576cellular_componentextracellular region
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0007155biological_processcell adhesion
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0008239molecular_functiondipeptidyl-peptidase activity
A0008284biological_processpositive regulation of cell population proliferation
A0009986cellular_componentcell surface
A0010716biological_processnegative regulation of extracellular matrix disassembly
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016787molecular_functionhydrolase activity
A0030027cellular_componentlamellipodium
A0030139cellular_componentendocytic vesicle
A0031258cellular_componentlamellipodium membrane
A0031295biological_processT cell costimulation
A0042803molecular_functionprotein homodimerization activity
A0042995cellular_componentcell projection
A0043542biological_processendothelial cell migration
A0045121cellular_componentmembrane raft
A0070161cellular_componentanchoring junction
B0002020molecular_functionprotease binding
B0004177molecular_functionaminopeptidase activity
B0004252molecular_functionserine-type endopeptidase activity
B0005102molecular_functionsignaling receptor binding
B0005576cellular_componentextracellular region
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0007155biological_processcell adhesion
B0008233molecular_functionpeptidase activity
B0008236molecular_functionserine-type peptidase activity
B0008239molecular_functiondipeptidyl-peptidase activity
B0008284biological_processpositive regulation of cell population proliferation
B0009986cellular_componentcell surface
B0010716biological_processnegative regulation of extracellular matrix disassembly
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0016787molecular_functionhydrolase activity
B0030027cellular_componentlamellipodium
B0030139cellular_componentendocytic vesicle
B0031258cellular_componentlamellipodium membrane
B0031295biological_processT cell costimulation
B0042803molecular_functionprotein homodimerization activity
B0042995cellular_componentcell projection
B0043542biological_processendothelial cell migration
B0045121cellular_componentmembrane raft
B0070161cellular_componentanchoring junction
C0002020molecular_functionprotease binding
C0004177molecular_functionaminopeptidase activity
C0004252molecular_functionserine-type endopeptidase activity
C0005102molecular_functionsignaling receptor binding
C0005576cellular_componentextracellular region
C0005886cellular_componentplasma membrane
C0006508biological_processproteolysis
C0007155biological_processcell adhesion
C0008233molecular_functionpeptidase activity
C0008236molecular_functionserine-type peptidase activity
C0008239molecular_functiondipeptidyl-peptidase activity
C0008284biological_processpositive regulation of cell population proliferation
C0009986cellular_componentcell surface
C0010716biological_processnegative regulation of extracellular matrix disassembly
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0016787molecular_functionhydrolase activity
C0030027cellular_componentlamellipodium
C0030139cellular_componentendocytic vesicle
C0031258cellular_componentlamellipodium membrane
C0031295biological_processT cell costimulation
C0042803molecular_functionprotein homodimerization activity
C0042995cellular_componentcell projection
C0043542biological_processendothelial cell migration
C0045121cellular_componentmembrane raft
C0070161cellular_componentanchoring junction
D0002020molecular_functionprotease binding
D0004177molecular_functionaminopeptidase activity
D0004252molecular_functionserine-type endopeptidase activity
D0005102molecular_functionsignaling receptor binding
D0005576cellular_componentextracellular region
D0005886cellular_componentplasma membrane
D0006508biological_processproteolysis
D0007155biological_processcell adhesion
D0008233molecular_functionpeptidase activity
D0008236molecular_functionserine-type peptidase activity
D0008239molecular_functiondipeptidyl-peptidase activity
D0008284biological_processpositive regulation of cell population proliferation
D0009986cellular_componentcell surface
D0010716biological_processnegative regulation of extracellular matrix disassembly
D0016020cellular_componentmembrane
D0016324cellular_componentapical plasma membrane
D0016787molecular_functionhydrolase activity
D0030027cellular_componentlamellipodium
D0030139cellular_componentendocytic vesicle
D0031258cellular_componentlamellipodium membrane
D0031295biological_processT cell costimulation
D0042803molecular_functionprotein homodimerization activity
D0042995cellular_componentcell projection
D0043542biological_processendothelial cell migration
D0045121cellular_componentmembrane raft
D0070161cellular_componentanchoring junction
Functional Information from PROSITE/UniProt
site_idPS00708
Number of Residues31
DetailsPRO_ENDOPEP_SER Prolyl endopeptidase family serine active site. DqieAtrqFskmgfvddkriaiwGwSyGGYV
ChainResidueDetails
AASP605-VAL635

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-LYS6
BMET1-LYS6
CMET1-LYS6
DMET1-LYS6

site_idSWS_FT_FI2
Number of Residues80
DetailsTRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255
ChainResidueDetails
AVAL7-LEU27
BVAL7-LEU27
CVAL7-LEU27
DVAL7-LEU27

site_idSWS_FT_FI3
Number of Residues2952
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ALEU28-PRO766
BLEU28-PRO766
CLEU28-PRO766
DLEU28-PRO766

site_idSWS_FT_FI4
Number of Residues12
DetailsACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU10084
ChainResidueDetails
ASER630
DSER630
DASP708
DHIS740
AASP708
AHIS740
BSER630
BASP708
BHIS740
CSER630
CASP708
CHIS740

site_idSWS_FT_FI5
Number of Residues24
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12690074
ChainResidueDetails
AASN85
BASN279
BASN321
BASN685
CASN85
CASN92
CASN229
CASN279
CASN321
CASN685
DASN85
AASN92
DASN92
DASN229
DASN279
DASN321
DASN685
AASN229
AASN279
AASN321
AASN685
BASN85
BASN92
BASN229

site_idSWS_FT_FI6
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
AASN150
DASN150
DASN179
DASN219
AASN179
AASN219
BASN150
BASN179
BASN219
CASN150
CASN179
CASN219

218853

PDB entries from 2024-04-24

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