5LIA
Crystal structure of murine autotaxin in complex with a small molecule inhibitor
Summary for 5LIA
Entry DOI | 10.2210/pdb5lia/pdb |
Descriptor | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, 1,2-ETHANEDIOL, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total) |
Functional Keywords | lysophospholipase d, autotaxin, enpp2, hydrolase |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 98955.72 |
Authors | Turnbull, A.P.,Shah, P.,Cheasty, A.,Raynham, T.,Pang, L.,Owen, P. (deposition date: 2016-07-14, release date: 2016-11-09, Last modification date: 2024-01-10) |
Primary citation | Shah, P.,Cheasty, A.,Foxton, C.,Raynham, T.,Farooq, M.,Gutierrez, I.F.,Lejeune, A.,Pritchard, M.,Turnbull, A.,Pang, L.,Owen, P.,Boyd, S.,Stowell, A.,Jordan, A.,Hamilton, N.M.,Hitchin, J.R.,Stockley, M.,MacDonald, E.,Quesada, M.J.,Trivier, E.,Skeete, J.,Ovaa, H.,Moolenaar, W.H.,Ryder, H. Discovery of potent inhibitors of the lysophospholipase autotaxin. Bioorg. Med. Chem. Lett., 26:5403-5410, 2016 Cited by PubMed: 27780639DOI: 10.1016/j.bmcl.2016.10.036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
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