5L9Z
Crystal structure of human heparanase nucleophile mutant (E343Q), in complex with unreacted glucuronic acid configured aziridine probe JJB355
Summary for 5L9Z
Entry DOI | 10.2210/pdb5l9z/pdb |
Descriptor | Heparanase, 2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-ETHANEDIOL, ... (7 entities in total) |
Functional Keywords | heparanase, probe, gh79, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 54043.17 |
Authors | Wu, L.,Jin, Y.,Davies, G.J. (deposition date: 2016-06-13, release date: 2017-05-31, Last modification date: 2024-01-10) |
Primary citation | Wu, L.,Jiang, J.,Jin, Y.,Kallemeijn, W.W.,Kuo, C.L.,Artola, M.,Dai, W.,van Elk, C.,van Eijk, M.,van der Marel, G.A.,Codee, J.D.C.,Florea, B.I.,Aerts, J.M.F.G.,Overkleeft, H.S.,Davies, G.J. Activity-based probes for functional interrogation of retaining beta-glucuronidases. Nat. Chem. Biol., 13:867-873, 2017 Cited by PubMed: 28581485DOI: 10.1038/nchembio.2395 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.57 Å) |
Structure validation
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