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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5L9Z

Crystal structure of human heparanase nucleophile mutant (E343Q), in complex with unreacted glucuronic acid configured aziridine probe JJB355

Functional Information from GO Data
ChainGOidnamespacecontents
A0016020cellular_componentmembrane
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues129
DetailsRegion: {"description":"Required for heterodimerization with the heparanase 8 kDa subunit","evidences":[{"source":"PubMed","id":"12927802","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues16
DetailsRegion: {"description":"Required for transferring proheparanase to the Golgi apparatus, secretion and subsequent enzyme activity and for enhancement of PKB/AKT1 phosphorylation"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15760902","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E9C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E9C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14573609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14573609","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14573609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14573609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E8M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14573609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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