5KIT
Crystal Structure of Nicotinamide Phosphoribosyltransferase (Nampt) in Complex with Inhibitors 37
Summary for 5KIT
Entry DOI | 10.2210/pdb5kit/pdb |
Descriptor | Nicotinamide phosphoribosyltransferase, ~{tert}-butyl (2~{S})-2-[(1,3-dihydropyrrolo[3,4-c]pyridin-2-ylcarbonylamino)methyl]-6-azaspiro[2.5]octane-6-carboxylate, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P43490 |
Total number of polymer chains | 2 |
Total formula weight | 113091.29 |
Authors | |
Primary citation | Zak, M.,Yuen, P.W.,Liu, X.,Patel, S.,Sampath, D.,Oeh, J.,Liederer, B.M.,Wang, W.,O'Brien, T.,Xiao, Y.,Skelton, N.,Hua, R.,Sodhi, J.,Wang, Y.,Zhang, L.,Zhao, G.,Zheng, X.,Ho, Y.C.,Bair, K.W.,Dragovich, P.S. Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors. J.Med.Chem., 59:8345-8368, 2016 Cited by PubMed: 27541271DOI: 10.1021/acs.jmedchem.6b00697 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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