5KIT
Crystal Structure of Nicotinamide Phosphoribosyltransferase (Nampt) in Complex with Inhibitors 37
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0006741 | biological_process | NADP+ biosynthetic process |
| A | 0006769 | biological_process | nicotinamide metabolic process |
| A | 0006954 | biological_process | inflammatory response |
| A | 0007165 | biological_process | signal transduction |
| A | 0007267 | biological_process | cell-cell signaling |
| A | 0007623 | biological_process | circadian rhythm |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0008286 | biological_process | insulin receptor signaling pathway |
| A | 0009435 | biological_process | NAD+ biosynthetic process |
| A | 0010628 | biological_process | positive regulation of gene expression |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| A | 0030054 | cellular_component | cell junction |
| A | 0032922 | biological_process | circadian regulation of gene expression |
| A | 0034355 | biological_process | NAD+ biosynthetic process via the salvage pathway |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0047280 | molecular_function | nicotinamide phosphoribosyltransferase activity |
| A | 0048511 | biological_process | rhythmic process |
| A | 0060612 | biological_process | adipose tissue development |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| A | 1901847 | biological_process | nicotinate metabolic process |
| B | 0005125 | molecular_function | cytokine activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005829 | cellular_component | cytosol |
| B | 0006741 | biological_process | NADP+ biosynthetic process |
| B | 0006769 | biological_process | nicotinamide metabolic process |
| B | 0006954 | biological_process | inflammatory response |
| B | 0007165 | biological_process | signal transduction |
| B | 0007267 | biological_process | cell-cell signaling |
| B | 0007623 | biological_process | circadian rhythm |
| B | 0008284 | biological_process | positive regulation of cell population proliferation |
| B | 0008286 | biological_process | insulin receptor signaling pathway |
| B | 0009435 | biological_process | NAD+ biosynthetic process |
| B | 0010628 | biological_process | positive regulation of gene expression |
| B | 0016607 | cellular_component | nuclear speck |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| B | 0030054 | cellular_component | cell junction |
| B | 0032922 | biological_process | circadian regulation of gene expression |
| B | 0034355 | biological_process | NAD+ biosynthetic process via the salvage pathway |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| B | 0047280 | molecular_function | nicotinamide phosphoribosyltransferase activity |
| B | 0048511 | biological_process | rhythmic process |
| B | 0060612 | biological_process | adipose tissue development |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| B | 1901847 | biological_process | nicotinate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue 6TA A 501 |
| Chain | Residue |
| A | HIS191 |
| A | HOH617 |
| A | HOH855 |
| A | HOH876 |
| B | TYR18 |
| A | PHE193 |
| A | ARG196 |
| A | ASP219 |
| A | ALA244 |
| A | SER275 |
| A | ARG311 |
| A | ILE351 |
| A | ALA379 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 A 502 |
| Chain | Residue |
| A | ARG392 |
| A | SER398 |
| A | LYS400 |
| A | EDO504 |
| A | HOH623 |
| A | HOH772 |
| A | HOH791 |
| A | HOH856 |
| B | ARG196 |
| B | HOH644 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue PO4 A 503 |
| Chain | Residue |
| A | ARG196 |
| A | GLU246 |
| A | HIS247 |
| A | ARG311 |
| A | ASP313 |
| A | HOH640 |
| A | HOH956 |
| B | TYR18 |
| B | HOH620 |
| B | HOH698 |
| B | HOH812 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | ARG40 |
| A | ARG392 |
| A | ASP393 |
| A | ASN396 |
| A | CYS397 |
| A | SER398 |
| A | PO4502 |
| A | HOH805 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | GLY315 |
| A | PRO317 |
| A | ASP354 |
| A | GLY355 |
| A | HOH646 |
| A | HOH734 |
| A | HOH871 |
| A | HOH908 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | GLU187 |
| A | VAL213 |
| A | ASN214 |
| A | LYS216 |
| A | ARG477 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 507 |
| Chain | Residue |
| A | PHE123 |
| A | VAL124 |
| A | ARG434 |
| A | ASN479 |
| A | HOH614 |
| A | HOH784 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 508 |
| Chain | Residue |
| A | GLY353 |
| A | GLY355 |
| A | GLY383 |
| A | GLY384 |
| A | HOH601 |
| A | HOH625 |
| A | HOH647 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | binding site for residue 6TA B 501 |
| Chain | Residue |
| A | TYR18 |
| B | HIS191 |
| B | PHE193 |
| B | ARG196 |
| B | ASP219 |
| B | VAL242 |
| B | ALA244 |
| B | SER275 |
| B | ILE309 |
| B | ARG311 |
| B | ALA379 |
| B | EDO504 |
| B | HOH878 |
| B | HOH973 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 B 502 |
| Chain | Residue |
| A | TYR18 |
| A | HOH623 |
| A | HOH755 |
| B | ARG196 |
| B | GLU246 |
| B | HIS247 |
| B | ARG311 |
| B | ASP313 |
| B | HOH625 |
| B | HOH644 |
| site_id | AD2 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 B 503 |
| Chain | Residue |
| B | HOH698 |
| B | HOH747 |
| B | HOH846 |
| A | ARG196 |
| B | ARG392 |
| B | SER398 |
| B | LYS400 |
| B | EDO505 |
| B | HOH620 |
| B | HOH675 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| A | ARG392 |
| B | PHE193 |
| B | ARG196 |
| B | 6TA501 |
| B | PO4508 |
| B | HOH644 |
| B | HOH873 |
| B | HOH928 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 505 |
| Chain | Residue |
| B | ARG40 |
| B | ARG392 |
| B | ASP393 |
| B | ASN396 |
| B | CYS397 |
| B | SER398 |
| B | PO4503 |
| B | HOH920 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 506 |
| Chain | Residue |
| A | HIS247 |
| A | SER248 |
| A | THR251 |
| A | HOH956 |
| B | LYS400 |
| B | CYS401 |
| B | PHE414 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 507 |
| Chain | Residue |
| A | LYS77 |
| B | GLU326 |
| B | HOH631 |
| B | HOH981 |
| site_id | AD7 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 B 508 |
| Chain | Residue |
| B | GLY353 |
| B | GLY355 |
| B | SER382 |
| B | GLY383 |
| B | GLY384 |
| B | EDO504 |
| B | HOH621 |
| B | HOH659 |
| B | HOH661 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 509 |
| Chain | Residue |
| A | HOH645 |
| B | GLY315 |
| B | PRO317 |
| B | ASP354 |
| B | GLY355 |
| B | HOH803 |
| B | HOH941 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
