5KIT
Crystal Structure of Nicotinamide Phosphoribosyltransferase (Nampt) in Complex with Inhibitors 37
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nicotinamide phosphoribosyltransferase | polymer | 491 | 55594.9 | 2 | UniProt (P43490) Pfam (PF18127) Pfam (PF04095) | Homo sapiens (Human) | Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin |
| 2 | C, K (A, B) | ~{tert}-butyl (2~{S})-2-[(1,3-dihydropyrrolo[3,4-c]pyridin-2-ylcarbonylamino)methyl]-6-azaspiro[2.5]octane-6-carboxylate | non-polymer | 386.5 | 2 | Chemie (6TA) | |||
| 3 | D, E, J, L, M... (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 6 | Chemie (PO4) | |||
| 4 | F, G, H, I, N... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 5 | T, U (A, B) | water | water | 18.0 | 1182 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 111189.9 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1901.4 | |
| All* | Total formula weight | 113091.3 |
