5KDF
Inorganic pyrophosphatase from Mycobacterium tuberculosis in complex with inhibitor 6 and inorganic pyrophosphate
Summary for 5KDF
Entry DOI | 10.2210/pdb5kdf/pdb |
Related | 5KDE |
Descriptor | Inorganic pyrophosphatase, ~{N}2,~{N}2,~{N}4,~{N}4-tetramethyl-6-(1-phenylpyrrol-2-yl)-1,3,5-triazine-2,4-diamine, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase, pyrophosphatase, drug target, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Cellular location | Cytoplasm : P9WI55 |
Total number of polymer chains | 1 |
Total formula weight | 20059.44 |
Authors | Pang, A.H.,Garzan, A.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2016-06-08, release date: 2016-09-28, Last modification date: 2023-09-27) |
Primary citation | Pang, A.H.,Garzan, A.,Larsen, M.J.,McQuade, T.J.,Garneau-Tsodikova, S.,Tsodikov, O.V. Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis. ACS Chem. Biol., 11:3084-3092, 2016 Cited by PubMed: 27622287DOI: 10.1021/acschembio.6b00510 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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