5K65
Crystal structure of VEGF binding IgG1-Fc (Fcab CT6)
Summary for 5K65
Entry DOI | 10.2210/pdb5k65/pdb |
Descriptor | Ig gamma-1 chain C region, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | immune system, antibody engineering, immunoglobulin g1, fc fragment, glycosylations, ch3 domain, fcab, vegf, vascular endothelial growth factor |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted : P01857 |
Total number of polymer chains | 2 |
Total formula weight | 54188.14 |
Authors | Humm, A.,Lobner, E.,Kitzmuller, M.,Mlynek, G.,Obinger, C.,Djinovic-Carugo, K. (deposition date: 2016-05-24, release date: 2017-09-06, Last modification date: 2024-01-10) |
Primary citation | Lobner, E.,Humm, A.S.,Mlynek, G.,Kubinger, K.,Kitzmuller, M.,Traxlmayr, M.W.,Djinovic-Carugo, K.,Obinger, C. Two-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 angstrom crystal structure of the complex. MAbs, 9:1088-1104, 2017 Cited by PubMed: 28816592DOI: 10.1080/19420862.2017.1364825 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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