5K65
Crystal structure of VEGF binding IgG1-Fc (Fcab CT6)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ig gamma-1 chain C region | polymer | 228 | 26008.6 | 2 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (Human) | |
| 2 | C (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1260.2 | 1 | In PDB GlyTouCan (G45889JQ) | |||
| 3 | D (D) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 81 | Chemie (HOH) |
Sequence modifications
A, B: 225 - 447 (UniProt: P01857)
| PDB | External Database | Details |
|---|---|---|
| Arg 359 | Thr 242 | engineered mutation |
| Phe 360 | Lys 243 | engineered mutation |
| Tyr 361 | Asn 244 | engineered mutation |
| Asp 388 | Glu 271 | engineered mutation |
| Ile 389 | Asn 272 | engineered mutation |
| Phe 389 | - | insertion |
| Pro 389 | - | insertion |
| Asn 389 | - | insertion |
| Gly 389 | - | insertion |
| Leu 389 | - | insertion |
| Pro 413 | Asp 296 | engineered mutation |
| Tyr 414 | Lys 297 | engineered mutation |
| Pro 415 | Ser 298 | engineered mutation |
| Ser 416 | Arg 299 | engineered mutation |
| Leu 418 | Gln 301 | engineered mutation |
| Met 419 | Gln 302 | engineered mutation |
| Thr 421 | Asn 304 | engineered mutation |
| Arg 422 | Val 305 | engineered mutation |
| His 440 | Ser 323 | engineered mutation |
| Glu 442 | Ser 325 | engineered mutation |
| Tyr 443 | Leu 326 | engineered mutation |
| Gln 444 | Ser 327 | engineered mutation |
| Trp 445 | Pro 328 | engineered mutation |
| Pro 446 | Gly 329 | engineered mutation |
| Thr 447 | Lys 330 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 52017.2 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2171.0 | |
| All* | Total formula weight | 54188.1 |
