5J5T

GLK co-crystal structure with aminopyrrolopyrimidine inhibitor

Summary for 5J5T

• Entry DOI: 10.2210/pdb5j5t/pdb
• Descriptor: Mitogen-activated protein kinase kinase kinase kinase 3, 5-[2-(piperidin-4-yl)-1,3-thiazol-5-yl]-3-[(pyridin-4-yl)methoxy]pyridin-2-amine (3 entities in total)
• Functional Keywords: protein kinsae, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 42593.44

Authors

Silvian, L.F.,Marcotte, D. (deposition date: 2016-04-03, release date: 2016-10-26, Last modification date: 2024-04-03)

• Primary citation: Marcotte, D.,Rushe, M.,M Arduini, R.,Lukacs, C.,Atkins, K.,Sun, X.,Little, K.,Cullivan, M.,Paramasivam, M.,Patterson, T.A.,Hesson, T.,D McKee, T.,May-Dracka, T.L.,Xin, Z.,Bertolotti-Ciarlet, A.,Bhisetti, G.R.,Lyssikatos, J.P.,Silvian, L.F.; Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension.; Protein Sci., 26:152-162, 2017; PubMed: 27727493; DOI: 10.1002/pro.3062

Experimental method

X-RAY DIFFRACTION (2.85 Å)