5J5T
GLK co-crystal structure with aminopyrrolopyrimidine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase kinase kinase kinase 3 | polymer | 370 | 42226.0 | 1 | UniProt (Q8IVH8) Pfam (PF00069) | Homo sapiens (Human) | Germinal center kinase-related protein kinase,GLK,MAPK/ERK kinase kinase kinase 3,MEKKK 3 |
| 2 | B (A) | 5-[2-(piperidin-4-yl)-1,3-thiazol-5-yl]-3-[(pyridin-4-yl)methoxy]pyridin-2-amine | non-polymer | 367.5 | 1 | Chemie (6G2) | |||
| 3 | C (A) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A: 13 - 380 (UniProt: Q8IVH8)
| PDB | External Database | Details |
|---|---|---|
| Gly 11 | - | expression tag |
| Ser 12 | - | expression tag |
| Ala 170 | Ser 170 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42226.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 367.5 | |
| All* | Total formula weight | 42593.4 |
