5J5S

Src kinase in complex with a sulfonamide inhibitor

Summary for 5J5S

• Entry DOI: 10.2210/pdb5j5s/pdb
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, N-{4-[8-amino-3-(propan-2-yl)imidazo[1,5-a]pyrazin-1-yl]naphthalen-1-yl}-N'-[3-(trifluoromethyl)phenyl]urea (3 entities in total)
• Functional Keywords: protein kinase, inactive kinase, sulfonamide inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Gallus gallus (Chicken)
• Cellular location: Cell membrane : P00523
• Total number of polymer chains: 2
• Total formula weight: 66462.30

Authors

Lebedev, I.,Feldman, H.C.,Georghiou, G.,Maly, D.J.,Seeliger, M. (deposition date: 2016-04-03, release date: 2016-06-01, Last modification date: 2023-09-27)

• Primary citation: Feldman, H.C.,Tong, M.,Wang, L.,Meza-Acevedo, R.,Gobillot, T.A.,Gliedt, M.J.,Hari, S.B.,Mitra, A.K.,Backes, B.J.,Papa, F.R.,Seeliger, M.A.,Maly, D.J.; Structural and Functional Analysis of the Allosteric Modulation of IRE1a with ATP-Competitive Kinase Inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.153 Å)