5GTZ
Crystal structure of EGFR 696-1022 T790M in complex with JTS-1-39
Summary for 5GTZ
Entry DOI | 10.2210/pdb5gtz/pdb |
Related | 5GMP 5GNK 5GTY |
Descriptor | Epidermal growth factor receptor, N-[5-[[5-chloranyl-4-[(2-propan-2-ylsulfonylphenyl)amino]pyrimidin-2-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxy-phenyl]prop-2-enamide, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | egfr, t790m, jts-1-39, inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 38690.29 |
Authors | |
Primary citation | Yan, X.E.,Yun, C.H. Crystal structure of EGFR 696-1022 T790M in complex with JTS-1-39 To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.999 Å) |
Structure validation
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