5G64

The complex between human IgE-Fc and two anti-IgE Fab fragments

Summary for 5G64

Entry DOI	10.2210/pdb5g64/pdb
Descriptor	IG EPSILON CHAIN C REGION, FAB FRAGMENT, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	immune system, immunoglobulin e, omalizumab, ige-fc
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	6
Total formula weight	171887.04
Authors	Davies, A.M.,Allan, E.G.,Keeble, A.H.,Delgado, J.,Cossins, B.P.,Mitropoulou, A.N.,Pang, M.O.Y.,Ceska, T.,Beavil, A.J.,Craggs, G.,Westwood, M.,Henry, A.J.,McDonnell, J.M.,Sutton, B.J. (deposition date: 2016-06-14, release date: 2017-05-03, Last modification date: 2024-01-10)
Primary citation	Davies, A.M.,Allan, E.G.,Keeble, A.H.,Delgado, J.,Cossins, B.P.,Mitropoulou, A.N.,Pang, M.O.Y.,Ceska, T.,Beavil, A.J.,Craggs, G.,Westwood, M.,Henry, A.J.,McDonnell, J.M.,Sutton, B.J. Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab. J. Biol. Chem., 292:9975-9987, 2017 Cited by PubMed: 28438838 DOI: 10.1074/jbc.M117.776476 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.715 Å)

Structure validation