5G55
3-Quinoline Carboxamides inhibitors of Pi3K
Summary for 5G55
Entry DOI | 10.2210/pdb5g55/pdb |
Descriptor | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, 6-cyano-4-[[(1R)-1-(4-methylphenyl)ethyl]amino]quinoline-3-carboxamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | transferase, atm |
Biological source | HOMO SAPIENS |
Total number of polymer chains | 1 |
Total formula weight | 111182.61 |
Authors | Edman, K.,Phillips, C. (deposition date: 2016-05-20, release date: 2016-08-03, Last modification date: 2024-05-08) |
Primary citation | Degorce, S.L.,Barlaam, B.,Cadogan, E.,Dishington, A.P.,Ducray, R.,Glossop, S.C.,Hassall, L.A.,Lach, F.,Lau, A.,Mcguire, T.M.,Nowak, T.,Ouvry, G.,Pike, K.G.,Thomason, A.G. Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (Atm) Kinase. J.Med.Chem., 59:6281-, 2016 Cited by PubMed: 27259031DOI: 10.1021/ACS.JMEDCHEM.6B00519 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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