5FNV
a new complex structure of tubulin with an alpha-beta unsaturated lactone
Summary for 5FNV
Entry DOI | 10.2210/pdb5fnv/pdb |
Descriptor | TUBULIN ALPHA-1B CHAIN, PIRONETIN, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | structural protein, tubulin complex alpha-beta unsaturated lactone |
Biological source | GALLUS GALLUS (CHICKEN) More |
Cellular location | Cytoplasm, cytoskeleton: Q2XVP4 P02554 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 264899.44 |
Authors | Wang, Y.,Naismith, J.,Zhu, X. (deposition date: 2015-11-16, release date: 2016-05-18, Last modification date: 2024-01-10) |
Primary citation | Yang, J.,Wang, Y.,Wang, T.,Jiang, J.,Botting, C.H.,Liu, H.,Chen, Q.,Yang, J.,Naismith, J.H.,Zhu, X.,Chen, L. Pironetin Reacts Covalently with Cysteine-316 of Alpha-Tubulin to Destabilize Microtubule. Nat.Commun., 7:12103-, 2016 Cited by PubMed: 27357539DOI: 10.1038/NCOMMS12103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
Download full validation report