5FMG
Structure and function based design of Plasmodium-selective proteasome inhibitors
Summary for 5FMG
Entry DOI | 10.2210/pdb5fmg/pdb |
EMDB information | 3231 |
Descriptor | PROTEASOME SUBUNIT ALPHA, PUTATIVE, BETA3 PROTEASOME SUBUNIT, PUTATIVE, PROTEASOME SUBUNIT BETA TYPE, ... (15 entities in total) |
Functional Keywords | hydrolase, proteasome, 20s, plasmodium, malaria, inhibitor, drug design, cryo-em |
Biological source | PLASMODIUM FALCIPARUM More |
Cellular location | Nucleus : Q8IAR3 C6KST3 Q8IK90 O77396 Cytoplasm . Nucleus : Q8I261 Q8IKC9 Q8IJT1 C0H4E8 Q7K6A9 Q8IDG3 Q8IDG2 Q8IBI3 Q8I6T3 |
Total number of polymer chains | 28 |
Total formula weight | 764272.01 |
Authors | Li, H.,O'Donoghue, A.J.,van der Linden, W.A.,Xie, S.C.,Yoo, E.,Foe, I.T.,Tilley, L.,Craik, C.S.,da Fonseca, P.C.A.,Bogyo, M. (deposition date: 2015-11-04, release date: 2016-03-02, Last modification date: 2017-08-23) |
Primary citation | Li, H.,O'Donoghue, A.J.,Van Der Linden, W.A.,Xie, S.C.,Yoo, E.,Foe, I.T.,Tilley, L.,Craik, C.S.,Da Fonseca, P.C.A.,Bogyo, M. Structure and Function Based Design of Plasmodium-Selective Proteasome Inhibitors Nature, 530:233-, 2016 Cited by PubMed: 26863983DOI: 10.1038/NATURE16936 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
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