5FH8

Crystal structure of the fifth bromodomain of human PB1 in complex with compound 28

Summary for 5FH8

Entry DOI	10.2210/pdb5fh8/pdb
Descriptor	Protein polybromo-1, 6-chloranyl-3-(2-ethylbutyl)-4~{H}-pyrrolo[1,2-a]quinazolin-5-one, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	pbrm1, brg1-associated factor 180, transcription, chromatin remodeling
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: Q86U86
Total number of polymer chains	4
Total formula weight	59943.40
Authors	Tallant, C.,Sutherell, C.L.,Siejka, P.,Sorrell, F.J.,Krojer, T.,Picaud, S.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Brennan, P.E.,Ley, S.V.,Knapp, S. (deposition date: 2015-12-21, release date: 2016-06-01, Last modification date: 2024-01-10)
Primary citation	Sutherell, C.L.,Tallant, C.,Monteiro, O.P.,Yapp, C.,Fuchs, J.E.,Fedorov, O.,Siejka, P.,Muller, S.,Knapp, S.,Brenton, J.D.,Brennan, P.E.,Ley, S.V. Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex. J.Med.Chem., 59:5095-5101, 2016 Cited by PubMed: 27119626 DOI: 10.1021/acs.jmedchem.5b01997 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation