5FH8
Crystal structure of the fifth bromodomain of human PB1 in complex with compound 28
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Protein polybromo-1 | polymer | 124 | 14648.0 | 4 | UniProt (Q86U86) Pfam (PF00439) | Homo sapiens (Human) | hPB1,BRG1-associated factor 180,BAF180,Polybromo-1D |
| 2 | E, G, H, I (A, B, C, D) | 6-chloranyl-3-(2-ethylbutyl)-4~{H}-pyrrolo[1,2-a]quinazolin-5-one | non-polymer | 302.8 | 4 | Chemie (5XK) | |||
| 3 | F (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 4 | J (D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 257 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 645 - 766 (UniProt: Q86U86)
| PDB | External Database | Details |
|---|---|---|
| Ser 643 | - | expression tag |
| Met 644 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 58592.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1351.4 | |
| All* | Total formula weight | 59943.4 |
