5EW8
FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH JNJ-4275693
Summary for 5EW8
Entry DOI | 10.2210/pdb5ew8/pdb |
Descriptor | Fibroblast growth factor receptor 1, SULFATE ION, ~{N}'-(3,5-dimethoxyphenyl)-~{N}'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-~{N}-propan-2-yl-ethane-1,2-diamine, ... (4 entities in total) |
Functional Keywords | fgfr1 kinase inhibitor complex, kinase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein: P11362 |
Total number of polymer chains | 2 |
Total formula weight | 71451.96 |
Authors | |
Primary citation | Patani, H.,Bunney, T.D.,Thiyagarajan, N.,Norman, R.A.,Ogg, D.,Breed, J.,Ashford, P.,Potterton, A.,Edwards, M.,Williams, S.V.,Thomson, G.S.,Pang, C.S.,Knowles, M.A.,Breeze, A.L.,Orengo, C.,Phillips, C.,Katan, M. Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use. Oncotarget, 7:24252-24268, 2016 Cited by PubMed: 26992226DOI: 10.18632/oncotarget.8132 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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