5ES1

CRYSTAL STRUCTURE OF MICROTUBULE AFFINITY-REGULATING KINASE 4 CATALYTIC DOMAIN IN COMPLEX WITH A PYRAZOLOPYRIMIDINE INHIBITOR

Summary for 5ES1

Entry DOI	10.2210/pdb5es1/pdb
Descriptor	MAP/microtubule affinity-regulating kinase 4, ~{N}-[(1~{R},6~{R})-6-azanyl-2,2-bis(fluoranyl)cyclohexyl]-5-ethyl-4-[6-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide (3 entities in total)
Functional Keywords	mark4 par-1 serine/threonine protein kinase11, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q96L34
Total number of polymer chains	1
Total formula weight	38092.83
Authors	Sack, J.S. (deposition date: 2015-11-16, release date: 2015-12-02, Last modification date: 2023-09-27)
Primary citation	Sack, J.S.,Gao, M.,Kiefer, S.E.,Myers, J.E.,Newitt, J.A.,Wu, S.,Yan, C. Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor. Acta Crystallogr F Struct Biol Commun, 72:129-134, 2016 Cited by PubMed: 26841763 DOI: 10.1107/S2053230X15024747 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation