5EKV
Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.
Summary for 5EKV
Entry DOI | 10.2210/pdb5ekv/pdb |
Descriptor | Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1, 3-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione (3 entities in total) |
Functional Keywords | complex, inhibitor, translation, eif4e |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm, P-body : P06730 |
Total number of polymer chains | 4 |
Total formula weight | 54769.63 |
Authors | Nowicki, M.W.,Walkinshaw, M.D.,Fischer, P.M. (deposition date: 2015-11-04, release date: 2016-09-07, Last modification date: 2024-01-10) |
Primary citation | Soukarieh, F.,Nowicki, M.W.,Bastide, A.,Poyry, T.,Jones, C.,Dudek, K.,Patwardhan, G.,Meullenet, F.,Oldham, N.J.,Walkinshaw, M.D.,Willis, A.E.,Fischer, P.M. Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124:200-217, 2016 Cited by PubMed: 27592390DOI: 10.1016/j.ejmech.2016.08.047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.61 Å) |
Structure validation
Download full validation report