5EK0
Human Nav1.7-VSD4-NavAb in complex with GX-936.
Summary for 5EK0
Entry DOI | 10.2210/pdb5ek0/pdb |
Descriptor | Chimera of bacterial Ion transport protein and human Sodium channel protein type 9 subunit alpha, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-cyano-4-[2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]-4-(trifluoromethyl)phenoxy]-~{N}-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (3 entities in total) |
Functional Keywords | membrane protein, ion channel, voltage-gated sodium channel, small molecule antagonist, metal transport |
Biological source | Arcobacter butzleri, Homo sapiens |
Total number of polymer chains | 4 |
Total formula weight | 155032.46 |
Authors | Ahuja, S.,Mukund, S.,Starovasnik, M.A.,Koth, C.M.,Payandeh, J. (deposition date: 2015-11-03, release date: 2015-12-23, Last modification date: 2023-09-27) |
Primary citation | Ahuja, S.,Mukund, S.,Deng, L.,Khakh, K.,Chang, E.,Ho, H.,Shriver, S.,Young, C.,Lin, S.,Johnson, J.P.,Wu, P.,Li, J.,Coons, M.,Tam, C.,Brillantes, B.,Sampang, H.,Mortara, K.,Bowman, K.K.,Clark, K.R.,Estevez, A.,Xie, Z.,Verschoof, H.,Grimwood, M.,Dehnhardt, C.,Andrez, J.C.,Focken, T.,Sutherlin, D.P.,Safina, B.S.,Starovasnik, M.A.,Ortwine, D.F.,Franke, Y.,Cohen, C.J.,Hackos, D.H.,Koth, C.M.,Payandeh, J. Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist. Science, 350:aac5464-aac5464, 2015 Cited by PubMed: 26680203DOI: 10.1126/science.aac5464 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.53 Å) |
Structure validation
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