Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5EK0

Human Nav1.7-VSD4-NavAb in complex with GX-936.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue PX4 A 1801

Chain	Residue
A	LEU1654
A	PHE1655
A	TYR1694
A	PRO1695
A	TYR1696
D	ARG1599

site_id	AC2
Number of Residues	7
Details	binding site for residue PX4 A 1802

Chain	Residue
A	PHE1670
A	TYR1671
B	PRO1695
B	TRP1698
A	THR1665
A	GLY1667
A	GLU1668

site_id	AC3
Number of Residues	1
Details	binding site for residue PX4 A 1804

Chain	Residue
A	GLN1618

site_id	AC4
Number of Residues	3
Details	binding site for residue PX4 A 1807

Chain	Residue
A	GLN1530
A	GLU1534
A	5P21808

site_id	AC5
Number of Residues	16
Details	binding site for residue 5P2 A 1808

Chain	Residue
A	GLU1534
A	TYR1537
A	TRP1538
A	ASN1540
A	VAL1541
A	GLY1581
A	MET1582
A	PHE1583
A	ALA1585
A	ASP1586
A	PHE1598
A	ARG1602
A	ALA1604
A	ARG1605
A	ARG1608
A	PX41807

site_id	AC6
Number of Residues	6
Details	binding site for residue PX4 B 1801

Chain	Residue
A	THR1596
A	ARG1599
B	TYR1694
B	PRO1695
B	TYR1696
B	ALA1697

site_id	AC7
Number of Residues	8
Details	binding site for residue PX4 B 1802

Chain	Residue
B	THR1665
B	GLY1667
B	GLU1668
B	PHE1670
B	TYR1671
C	MET1691
C	PRO1695
C	TRP1698

site_id	AC8
Number of Residues	1
Details	binding site for residue PX4 B 1803

Chain	Residue
B	GLN1618

site_id	AC9
Number of Residues	1
Details	binding site for residue PX4 B 1804

Chain	Residue
B	MET1677

site_id	AD1
Number of Residues	3
Details	binding site for residue PX4 B 1805

Chain	Residue
B	GLU1534
B	ASP1586
B	5P21806

site_id	AD2
Number of Residues	15
Details	binding site for residue 5P2 B 1806

Chain	Residue
B	GLU1534
B	TYR1537
B	TRP1538
B	ASN1540
B	VAL1541
B	GLY1581
B	MET1582
B	PHE1583
B	ALA1585
B	ASP1586
B	PHE1598
B	ARG1602
B	ARG1605
B	ARG1608
B	PX41805

site_id	AD3
Number of Residues	4
Details	binding site for residue PX4 C 1801

Chain	Residue
B	THR1596
C	TYR1694
C	PRO1695
C	TYR1696

site_id	AD4
Number of Residues	7
Details	binding site for residue PX4 C 1802

Chain	Residue
C	TYR1645
C	THR1665
C	GLY1667
C	GLU1668
C	PHE1670
D	TYR1696
D	TRP1698

site_id	AD5
Number of Residues	1
Details	binding site for residue PX4 C 1803

Chain	Residue
C	GLN1618

site_id	AD6
Number of Residues	3
Details	binding site for residue PX4 C 1804

Chain	Residue
C	GLU1534
C	TRP1538
C	5P21805

site_id	AD7
Number of Residues	16
Details	binding site for residue 5P2 C 1805

Chain	Residue
C	TYR1537
C	TRP1538
C	ASN1540
C	GLY1581
C	MET1582
C	PHE1583
C	ALA1585
C	ASP1586
C	GLU1589
C	THR1590
C	PHE1598
C	ARG1602
C	ALA1604
C	ARG1605
C	ARG1608
C	PX41804

site_id	AD8
Number of Residues	6
Details	binding site for residue PX4 D 1801

Chain	Residue
A	TRP1698
D	PHE1644
D	GLY1667
D	GLU1668
D	PHE1670
A	MET1691

site_id	AD9
Number of Residues	5
Details	binding site for residue PX4 D 1802

Chain	Residue
C	ARG1599
D	PHE1655
D	TYR1694
D	PRO1695
D	TYR1696

site_id	AE1
Number of Residues	2
Details	binding site for residue PX4 D 1805

Chain	Residue
D	GLU1534
D	5P21806

site_id	AE2
Number of Residues	17
Details	binding site for residue 5P2 D 1806

Chain	Residue
D	GLU1534
D	TYR1537
D	TRP1538
D	ASN1540
D	VAL1541
D	SER1578
D	GLY1581
D	MET1582
D	PHE1583
D	ALA1585
D	ASP1586
D	PHE1598
D	ARG1602
D	ALA1604
D	ARG1605
D	ARG1608
D	PX41805

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	56
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	80
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	48
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)