5EK0

Human Nav1.7-VSD4-NavAb in complex with GX-936.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Chimera of bacterial Ion transport protein and human Sodium channel protein type 9 subunit alpha	polymer	296	34618.1	4	UniProt (A8EVM5) UniProt (Q15858) Pfam (PF00520) Pfam (PF08016)	Arcobacter butzleri Homo sapiens	euroendocrine sodium channel,hNE-Na,Peripheral sodium channel 1,PN1,Sodium channel protein type IX subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.7
2	AA, BA, E, F, G... (D, A, B, C)	1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		678.9	21	Chemie (PX4)
3	CA, L, R, W (D, A, B, C)	3-cyano-4-[2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]-4-(trifluoromethyl)phenoxy]-~{N}-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	non-polymer		575.6	4	Chemie (5P2)

Sequence modifications

A, B, C, D: 1493 - 1515 (UniProt: A8EVM5)

PDB	External Database	Details
Met -17	-	initiating methionine
Asp -16	-	expression tag
Tyr -15	-	expression tag
Lys -14	-	expression tag
Asp -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Lys -9	-	expression tag
Gly -8	-	expression tag
Ser -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

A, B, C, D: 1516 - 1548 (UniProt: Q15858)
A, B, C, D: 1549 - 1569 (UniProt: A8EVM5)
A, B, C, D: 1570 - 1611 (UniProt: Q15858)
A, B, C, D: 1612 - 1770 (UniProt: A8EVM5)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	138472.4
Non-Polymers*	Number of molecules	25
	Total formula weight	16560.1
All*	Total formula weight	155032.5

*Water molecules are not included.