5EBZ
Crystal structure of human IKK1
Summary for 5EBZ
Entry DOI | 10.2210/pdb5ebz/pdb |
Descriptor | Inhibitor of nuclear factor kappa-B kinase subunit alpha, 2,3-di-O-sulfo-alpha-D-glucopyranose-(1-6)-alpha-D-glucopyranose-(1-6)-2,4-di-O-sulfo-alpha-D-glucopyranose, [(2S,3R,4S,5S,6R)-6-(hydroxymethyl)-2,4-bis(oxidanyl)-5-oxidanylsulfanyloxy-oxan-3-yl] hydrogen sulfate-(1-6)-(2S,3R,4R,5S,6R)-6-(hydroxymethyl)-5-oxidanylsulfanyloxy-oxane-2,3,4-triol-(1-6)-2-O-sulfo-alpha-D-glucopyranose-(1-6)-[(2R,3R,4R,5R,6S)-2-(hydroxymethyl)-5,6-bis(oxidanyl)-3-oxidanylsulfanyloxy-oxan-4-yl] hydrogen sulfate-(1-6)-[(2S,3R,4S,5R,6R)-6-(hydroxymethyl)-2,5-bis(oxidanyl)-4-oxidanylsulfanyloxy-oxan-3-yl] hydrogen sulfate-(1-6)-[(2R,3R,4R,5R,6S)-2-(hydroxymethyl)-5,6-bis(oxidanyl)-3-oxidanylsulfanyloxy-oxan-4-yl] hydrogen sulfate-(1-6)-2,4-di-O-sulfo-alpha-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 12 |
Total formula weight | 933780.01 |
Authors | Polley, S.,Passos, D.,Huang, D.,Biswas, T.,Verma, I.,Lyumkis, D.,Ghosh, G. (deposition date: 2015-10-20, release date: 2016-11-02, Last modification date: 2024-03-06) |
Primary citation | Polley, S.,Passos, D.O.,Huang, D.B.,Mulero, M.C.,Mazumder, A.,Biswas, T.,Verma, I.M.,Lyumkis, D.,Ghosh, G. Structural Basis for the Activation of IKK1/ alpha. Cell Rep, 17:1907-1914, 2016 Cited by PubMed: 27851956DOI: 10.1016/j.celrep.2016.10.067 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.5 Å) |
Structure validation
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