5EBZ
Crystal structure of human IKK1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Inhibitor of nuclear factor kappa-B kinase subunit alpha | polymer | 655 | 75146.9 | 12 | UniProt (O15111) Pfam (PF00069) Pfam (PF18397) | Homo sapiens (Human) | IkappaB kinase,Conserved helix-loop-helix ubiquitous kinase,I-kappa-B kinase 1,IKK1,Nuclear factor NF-kappa-B inhibitor kinase alpha,NFKBIKA,Transcription factor 16,TCF-16 |
| 2 | AA, BA, DA, EA, FA... (a, b, d, e, f...) | 2,3-di-O-sulfo-alpha-D-glucopyranose-(1-6)-alpha-D-glucopyranose-(1-6)-2,4-di-O-sulfo-alpha-D-glucopyranose | branched | 824.7 | 24 | In PDB GlyTouCan (G32438WU) | |||
| 3 | CA, IA, O, T (c, i, O, T) | [(2S,3R,4S,5S,6R)-6-(hydroxymethyl)-2,4-bis(oxidanyl)-5-oxidanylsulfanyloxy-oxan-3-yl] hydrogen sulfate-(1-6)-(2S,3R,4R,5S,6R)-6-(hydroxymethyl)-5-oxidanylsulfanyloxy-oxane-2,3,4-triol-(1-6)-2-O-sulfo-alpha-D-glucopyranose-(1-6)-[(2R,3R,4R,5R,6S)-2-(hydroxymethyl)-5,6-bis(oxidanyl)-3-oxidanylsulfanyloxy-oxan-4-yl] hydrogen sulfate-(1-6)-[(2S,3R,4S,5R,6R)-6-(hydroxymethyl)-2,5-bis(oxidanyl)-4-oxidanylsulfanyloxy-oxan-3-yl] hydrogen sulfate-(1-6)-[(2R,3R,4R,5R,6S)-2-(hydroxymethyl)-5,6-bis(oxidanyl)-3-oxidanylsulfanyloxy-oxan-4-yl] hydrogen sulfate-(1-6)-2,4-di-O-sulfo-alpha-D-glucopyranose | branched | 1953.8 | 4 | In PDB GlyTouCan (G51196UN) | |||
| 4 | OA, PA, QA, RA, SA... (A, B, C, D, E...) | 2-azanyl-5-phenyl-3-(4-sulfamoylphenyl)benzamide | non-polymer | 367.4 | 12 | Chemie (5TL) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 10 - 660 (UniProt: O15111)
| PDB | External Database | Details |
|---|---|---|
| Asp 6 | - | expression tag |
| Pro 7 | - | expression tag |
| Glu 8 | - | expression tag |
| Phe 9 | - | expression tag |
| Glu 176 | Ser 176 | engineered mutation |
| Glu 180 | Ser 180 | engineered mutation |
| Ile 268 | Val 268 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 901763.3 | |
| Branched | Number of molecules | 28 |
| Total formula weight | 27607.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4409.1 | |
| All* | Total formula weight | 933780.0 |
