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1NFK
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BU of 1nfk by Molmil
STRUCTURE OF THE NUCLEAR FACTOR KAPPA-B (NF-KB) P50 HOMODIMER
Descriptor: DNA (5'-D(*TP*GP*GP*GP*AP*AP*TP*TP*CP*CP*C)-3'), PROTEIN (NUCLEAR FACTOR KAPPA-B (NF-KB))
Authors:Ghosh, G, Van Duyne, G, Ghosh, S, Sigler, P.B.
Deposit date:1995-02-28
Release date:1996-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of NF-kappa B p50 homodimer bound to a kappa B site.
Nature, 373, 1995
5U01
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BU of 5u01 by Molmil
Cooperative DNA binding by two RelA dimers
Descriptor: DNA (27-MER), Transcription factor p65
Authors:Ghosh, G, Huang, D.
Deposit date:2016-11-22
Release date:2017-09-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor kappa B are not correlated.
J. Biol. Chem., 292, 2017
1BFS
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BU of 1bfs by Molmil
STRUCTURE OF NF-KB P50 HOMODIMER BOUND TO A KB SITE
Descriptor: NUCLEAR FACTOR NF-KAPPA-B P50
Authors:Huang, D.B, Huxford, T, Chen, Y.Q, Ghosh, G.
Deposit date:1997-09-12
Release date:1998-01-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits.
Structure, 5, 1997
1BFT
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BU of 1bft by Molmil
STRUCTURE OF NF-KB P50 HOMODIMER BOUND TO A KB SITE
Descriptor: NUCLEAR FACTOR NF-KAPPA-B P65
Authors:Huang, D.B, Huxford, T, Chen, Y.Q, Ghosh, G.
Deposit date:1997-09-12
Release date:1998-01-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits.
Structure, 5, 1997
1AIS
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BU of 1ais by Molmil
TATA-BINDING PROTEIN/TRANSCRIPTION FACTOR (II)B/TATA-BOX COMPLEX FROM PYROCOCCUS WOESEI
Descriptor: DNA (5'-D(*AP*AP*CP*TP*TP*AP*CP*TP*TP*TP*(5IU)P*(5IU)P*AP*AP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*TP*TP*AP*AP*AP*AP*AP*GP*TP*AP*AP*GP*TP*T )-3'), PROTEIN (TATA-BINDING PROTEIN), ...
Authors:Kosa, P.F, Ghosh, G, Dedecker, B.S, Sigler, P.B.
Deposit date:1997-04-24
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The 2.1-A crystal structure of an archaeal preinitiation complex: TATA-box-binding protein/transcription factor (II)B core/TATA-box.
Proc.Natl.Acad.Sci.USA, 94, 1997
1VKX
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BU of 1vkx by Molmil
CRYSTAL STRUCTURE OF THE NFKB P50/P65 HETERODIMER COMPLEXED TO THE IMMUNOGLOBULIN KB DNA
Descriptor: DNA (5'-D(*AP*GP*GP*AP*AP*AP*GP*TP*CP*CP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*GP*GP*AP*CP*TP*TP*TP*CP*C)-3'), PROTEIN (NF-KAPPA B P50 SUBUNIT), ...
Authors:Chen, F, Huang, D.B, Ghosh, G.
Deposit date:1997-09-17
Release date:1998-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA.
Nature, 391, 1998
2V2T
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BU of 2v2t by Molmil
X-ray structure of a NF-kB p50-RelB-DNA complex
Descriptor: 5'-D(*CP*GP*GP*GP*AP*AP*TP*TP*CP*CP*CP)-3', NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT, TRANSCRIPTION FACTOR RELB
Authors:Moorthy, A.K, Huang, D.B, Wang, V.Y, Vu, D, Ghosh, G.
Deposit date:2007-06-07
Release date:2007-07-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:X-Ray Structure of a NF-kappaB p50/Relb/DNA Complex Reveals Assembly of Multiple Dimers on Tandem kappaB Sites.
J.Mol.Biol., 373, 2007
4E3C
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BU of 4e3c by Molmil
X-ray crystal structure of human IKK2 in an active conformation
Descriptor: Inhibitor of nuclear factor kappa-B kinase subunit beta
Authors:Polley, S, Huang, D.B, Hauenstein, A.V, Ghosh, G, Huxford, T.
Deposit date:2012-03-09
Release date:2013-06-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.98 Å)
Cite:X-ray crystal structure of human IKK2 in an active conformation
Plos.Biol., 2013
3JV0
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BU of 3jv0 by Molmil
Crystal structure of a mutant of RelB dimerization domain(M6)
Descriptor: Transcription factor RelB
Authors:Vu, D, Huang, D.B, Ghosh, G.
Deposit date:2009-09-15
Release date:2010-11-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Instability of the RelB dimerization domain is functionally importent
To be Published
3JV5
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BU of 3jv5 by Molmil
Crystal structure of the dimerization domains p52 homodimer
Descriptor: Nuclear factor NF-kappa-B p100 subunit
Authors:Vu, D, Huang, D.B, Ghosh, G.
Deposit date:2009-09-15
Release date:2010-11-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Instability of the RelB dimerization domain is functionally important
To be Published
3JSS
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BU of 3jss by Molmil
Crystal structure of a mutant RelB dimerization domain
Descriptor: Transcription factor RelB
Authors:Vu, D, Huang, D.B, Ghosh, G.
Deposit date:2009-09-10
Release date:2010-11-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A structural basis for selective dimerization by NF-kappa B RelB.
J.Mol.Biol., 425, 2013
3JUZ
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BU of 3juz by Molmil
Crystal structure of a mutant of RelB dimerization domain(M5)
Descriptor: Transcription factor RelB
Authors:Vu, D, Huang, D.B, Ghosh, G.
Deposit date:2009-09-15
Release date:2010-11-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Instability of the RelB dimerization domain is functionally important
To be Published
3JV6
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BU of 3jv6 by Molmil
Crystal structure of the dimerization domains p52 and RelB
Descriptor: Nuclear factor NF-kappa-B p100 subunit, SULFATE ION, Transcription factor RelB
Authors:Vu, D, Huang, D.B, Ghosh, G.
Deposit date:2009-09-15
Release date:2010-11-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:A structural basis for selective dimerization by NF-kappa B RelB.
J.Mol.Biol., 425, 2013
3JV4
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BU of 3jv4 by Molmil
Crystal structure of the dimerization domains p50 and RelB
Descriptor: Nuclear factor NF-kappa-B p105 subunit, Transcription factor RelB
Authors:Vu, D, Huang, D.B, Ghosh, G.
Deposit date:2009-09-15
Release date:2010-11-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:A structural basis for selective dimerization by NF-kappa B RelB.
J.Mol.Biol., 425, 2013
1K3Z
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BU of 1k3z by Molmil
X-ray crystal structure of the IkBb/NF-kB p65 homodimer complex
Descriptor: Transcription factor p65, transcription factor inhibitor I-kappa-B-beta
Authors:Shiva, M, Huang, D.B, Chen, Y, Huxford, T, Ghosh, S, Ghosh, G.
Deposit date:2001-10-04
Release date:2002-10-04
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex.
J.Biol.Chem., 278, 2003
5TQX
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BU of 5tqx by Molmil
CryoEM reconstruction of human IKK1, intermediate conformation 2
Descriptor: Inhibitor of nuclear factor kappa-B kinase subunit alpha
Authors:Lyumkis, D, Ghosh, G, Polley, S, Biswath, T, Huang, D, Passos, D.O.
Deposit date:2016-10-24
Release date:2016-11-09
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.4 Å)
Cite:Structural Basis for the Activation of IKK1/ alpha.
Cell Rep, 17, 2016
5TQW
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BU of 5tqw by Molmil
CryoEM reconstruction of human IKK1, open conformation 1
Descriptor: Inhibitor of nuclear factor kappa-B kinase subunit alpha
Authors:Lyumkis, D, Ghosh, G, Polley, S, Biswath, T, Huang, D, Passos, D.O.
Deposit date:2016-10-24
Release date:2016-11-09
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:Structural Basis for the Activation of IKK1/ alpha.
Cell Rep, 17, 2016
5TQY
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BU of 5tqy by Molmil
CryoEM reconstruction of human IKK1, closed conformation 3
Descriptor: Inhibitor of nuclear factor kappa-B kinase subunit alpha
Authors:Lyumkis, D, Ghosh, G, Polley, S, Biswath, T, Huang, D, Passos, D.O.
Deposit date:2016-10-24
Release date:2016-11-09
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:Structural Basis for the Activation of IKK1/ alpha.
Cell Rep, 17, 2016
1OY3
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BU of 1oy3 by Molmil
CRYSTAL STRUCTURE OF AN IKBBETA/NF-KB P65 HOMODIMER COMPLEX
Descriptor: Transcription factor p65, transcription factor inhibitor I-kappa-B-beta
Authors:Malek, S, Huang, D.B, Huxford, T, Ghosh, S, Ghosh, G.
Deposit date:2003-04-03
Release date:2003-05-20
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex.
J.Biol.Chem., 278, 2003
1RAM
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BU of 1ram by Molmil
A NOVEL DNA RECOGNITION MODE BY NF-KB P65 HOMODIMER
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, DNA (5'-D(*CP*GP*GP*CP*TP*GP*GP*AP*AP*AP*TP*TP*TP*CP*CP*AP*GP*CP*CP*G)-3'), PROTEIN (TRANSCRIPTION FACTOR NF-KB P65)
Authors:Chen, Y.-Q, Ghosh, S, Ghosh, G.
Deposit date:1997-11-22
Release date:1998-05-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A novel DNA recognition mode by the NF-kappa B p65 homodimer.
Nat.Struct.Biol., 5, 1998
2RAM
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BU of 2ram by Molmil
A NOVEL DNA RECOGNITION MODE BY NF-KB P65 HOMODIMER
Descriptor: (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, DNA (5'-D(*CP*GP*GP*CP*TP*GP*GP*AP*AP*AP*TP*(5IU)P*(5IU)P*CP*CP*AP*GP*CP*CP*G)-3'), PROTEIN (TRANSCRIPTION FACTOR NF-KB P65)
Authors:Chen, Y.Q, Ghosh, S, Ghosh, G.
Deposit date:1997-11-23
Release date:1998-05-27
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A novel DNA recognition mode by the NF-kappa B p65 homodimer.
Nat.Struct.Biol., 5, 1998
1SGS
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BU of 1sgs by Molmil
Crystal structure of a free kB DNA
Descriptor: CALCIUM ION, kB DNA
Authors:Huang, D.B, Phelps, C.B, Fusco, A.J, Ghosh, G.
Deposit date:2004-02-24
Release date:2004-03-23
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of a free kappaB DNA: insights into DNA recognition by transcription factor NF-kappaB.
J.Mol.Biol., 346, 2005
1WAK
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BU of 1wak by Molmil
X-ray structure of SRPK1
Descriptor: 1,2-ETHANEDIOL, SERINE/THREONINE-PROTEIN KINASE SPRK1
Authors:Ngo, J.C, Gullingsrud, J, Chakrabarti, S, Nolen, B, Aubol, B.E, Fu, X.D, Adams, J.A, Mccammon, J.A, Ghosh, G.
Deposit date:2004-10-26
Release date:2006-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Sr Protein Kinase 1 is Resilient to Inactivation.
Structure, 15, 2007
1WBP
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BU of 1wbp by Molmil
SRPK1 bound to 9mer docking motif peptide
Descriptor: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, MEMBRANE-ASSOCIATED GUANYLATE KINASE, ...
Authors:Ngo, J.C, Gullinsgrud, J, Chakrabarti, S, Nolen, B, Aubol, B.E, Fu, X.-D, Adams, J.A, McCammon, J.A, Ghosh, G.
Deposit date:2004-11-04
Release date:2005-10-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Interplay between Srpk and Clk/Sty Kinases in Phosphorylation of the Splicing Factor Asf/Sf2 is Regulated by a Docking Motif in Asf/Sf2
Mol.Cell, 20, 2005
1XXA
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BU of 1xxa by Molmil
C-TERMINAL DOMAIN OF ESCHERICHIA COLI ARGININE REPRESSOR/ L-ARGININE COMPLEX; PB DERIVATIVE
Descriptor: ARGININE, ARGININE REPRESSOR, LEAD (II) ION
Authors:Van Duyne, G.D, Ghosh, G, Maas, W.K, Sigler, P.B.
Deposit date:1995-11-03
Release date:1996-03-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the oligomerization and L-arginine binding domain of the arginine repressor of Escherichia coli.
J.Mol.Biol., 256, 1996

 

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