5EBV

Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor 11c and CoA

Summary for 5EBV

• Entry DOI: 10.2210/pdb5ebv/pdb
• Related: 5EC4
• Descriptor: Enhanced intracellular survival protein, COENZYME A, 5-(4-chlorophenyl)-~{N}-[3-(3,4-dihydro-1~{H}-isoquinolin-2-yl)propyl]-4-methyl-1,1-bis(oxidanylidene)-1,2-thiazol-3-amine, ... (5 entities in total)
• Functional Keywords: transferase, aminoglycoside, resistance, tuberculosis, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 1
• Total formula weight: 47232.06

Authors

Gajadeera, C.S.,Hou, C.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2015-10-19, release date: 2016-03-30, Last modification date: 2024-03-06)

• Primary citation: Willby, M.J.,Green, K.D.,Gajadeera, C.S.,Hou, C.,Tsodikov, O.V.,Posey, J.E.,Garneau-Tsodikova, S.; Potent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosis.; Acs Chem.Biol., 11:1639-1646, 2016; PubMed: 27010218; DOI: 10.1021/acschembio.6b00110

Experimental method

X-RAY DIFFRACTION (2.2 Å)